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Gene expression profiling of the proliferative effect of periplocin on mouse cardiac microvascular endothelial cells |
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| Authors: | Xiao-ying Wang Xiu-mei Gao Hong Liu Han Zhang Yang Liu Min Jiang Li-min Hu and Bo-li Zhang |
| Institution: | WANG Xiao-ying,GAO Xiu-mei,LIU-Hong,ZHANG Han LIU Yang,JIANG Min,HU Li-min,, ZHANG Bo-li Institute of Traditional Chinese Medicine Research,Tianjin University of Traditional Chinese Medicine,Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae,Ministry of Education,Key Laboratory of Traditional Chinese Medicine Pharmacology,Tianjin(300193),China |
| Abstract: | Objective:Periplocin is an active digitalis-like component from Cortex Periplocae,which has been widely used in the treatment of heart diseases in China for many years.According to the recommendations on the cardiovascular effect of periplocin from in vivo experiments,subsequent in vitro experiments are greatly needed for the global assessment of periplocin.The objective of this study is to investigate the cell proliferation effect and the mechanism of periplocin on endothelial cells.Methods:The proliferati... |
| Keywords: | periplocin cardiac microvascular endothelial cells proliferation protein serine/threonine kinase GTP-binding |
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