251例血液透析患者HBsAg与抗-HCV检测结果分析

目的分析血液透析患者乙型肝炎表面抗原（HBsAg）与丙型肝炎抗体（抗-HCV）检测结果，旨在寻求血透患者感染的依据，减少医源性感染。方法应用酶联免疫吸附法（EuSA）检测2006年12月份在我院进行血液透析的251例患者HBsAg与抗-HCV，并对透析1年以上的149例患者的肝炎标志物阳性率与透析年限、输血史、手术史的相关性进行分析。结果透析1年以上的149例患者中，HBsAg阳性者19例，阳性率为12．8％；抗-HCV阳性者29例，阳性率19．5％。HB—sAg、抗-HCV同时为阳性者仅1例（0．4％）。抗-HCV阳性率随透析年限、输血次数、手术次数增加而增高（P〈0．05），多因素非条件多元Logistic回归分析提示，透析年限是抗-HCV阳性率最有统计学意义的因素（OR〉I）；而HBsAg阳性率与透析年限、输血、手术、性别的相关性均无明显统计学意义（P〉0．05）。结论透析年限、输血、手术与抗-HCV阳性率具有显著相关性，随着透析年限的增加抗-HCV阳性率上升，而与HBsAg阳性率无明显相关性。

The Status of Hepatitis B and Hepatitis C Virus Infection in Hemodialysis Patients

Objective To investigate the status of Hepatitis B and Hepatitis C virus infection in hemodialysis （HD） patients so as to strengthen the preventive strategies for the infection. Method Serum samples of the HD patients in our dialysis center in December, 2006 were tested for HBsAg and anti-HCV antibody by ELISA. The correlation of the incidenal of HBsAg ＋ and anti-HCV ＋ with the duration on HD, the history of blood transfusion and surgicol intervetion were analyzed. Results A- mong 149 patients with duration on Hdmore than 12 months, the positive percentage of HBsAg and anti- HCV is 12. 8% （19/149） and 19. 5%（29/149） respectively, and the percentage of the concurrent infection is 0.4% （only 1/149）. Single factor analysis showed that HCV infection was markedly associated with duration on HD, history and number of blood transfusion and surgicol intervetion （P〈 0. 05）. Logistic regression analysis showed that the duration on HD is the most important factor （OR〉1）. While single factor analysis showed that HBV infection was not significantly associated with the above factors（P〉0. 05）. Conclusions The infection of the HBV virus in our dialysis center is relatively well controlled, while the control of the HCV virus infection has to be strengthened.