结肠黑变病致病因素分析及与结肠肿瘤的关系探讨

目的 探讨结肠黑变病（melanosis coli，MC）的病因、发病特点，以及MC与结肠肿瘤、结肠腺瘤性息肉的关系。方法 对37名MC患者的临床资料（是否合并便秘，是否服用泻药以及服药方式、时间）、镜下表现及病理检查结果进行回顾性分析；同时统计同期非MC患者的腺瘤性息肉检出率及癌变率。结果 MC患者均有便秘史，其中31名患者有明确服用泻药史；37人中有3例发生腺瘤性息肉，其中2例癌变。结论 便秘及服用泻药是导致MC发生的重要因素；MC与结肠癌、结肠腺瘤性息肉的发生无统计学意义上的相关性。

Clinical analysis on melanosis coli: risk factor, relationship with colorectal neoplasia

[Objective] To evaluate the risk factor for Melanosis Coli.To investigate the relationship between Melanosis Coil and colorectal neoplasia. [Methods] 37 patients with melanosis coil diagnosed by endoscopy and histopathological examination were retrospectived analyzed on their history of constipation, laxatives use. [Results] All the cases had constipation and 31 cases had histroy of laxatives use.3 cases had colorectal adenomas with 2 of which had carcinoma. [Conclusion] Melanosis coli is mainly related with constipation and abuse of laxatives and but were not significant risk factors for the development of colorectal adenomas or colorectal carcinomas.