耐亚胺培南铜绿假单胞菌临床检出及耐药趋势分析

目的调查云南省安宁地区耐亚胺培南铜绿假单胞菌（IRPA）医院感染发生率及耐药谱,为临床合理用药提供参考。方法分析近3年IRPA医院感染患者的临床资料,把住院患者感染性标本中分离出的铜绿假单胞菌（PA）,采用K-B法进行体外耐药监测,并统计分析耐药率。结果 3年来医院感染性标本中共检出185株IRPA,检出率为38.8%,IRPA与非IRPA对常用抗菌药物的耐药率相比,差异有统计学意义（P〈0.05）,对多种抗生素的耐药性也有上升。结论 IRPA耐药情况比较严重,耐药机制复杂,有多重耐药性,建议重视对IRPA的监测与控制,尤其要关注泛耐药菌株的产生与流行。

Analysis of imipenem resistant Pseudomonas aeruginosa clinical detection and drug resistance trend

[ Objective ] To investigate Arming area Yunnan province nosocomial infection status and antibiotic resistance of imipenem-resistantPseudomonas aeruginosa（IRPA） to provide scientific evidence for clinical diagnosis and treatment. [ Methods ] We analyse the clinical data of the patients infected with IRPA for three years. Pseudomonas aeruginosa （PA） was isolated from in patients＇ specimen and antibiotic susceptibility testin vitrowas performed by K-B methods. [ Results ] During three years, 185 strains of IRPA were identified, the occurrence ratio was 38.8%. The resistance rates to the common antibiotics in IRPA were significantly higher than that in non-IRPA strains（P〈0.05）. The prevalence of IRPA and its resistantce to other antibiotics is increasing. [ Conclusion ] Because of the severe drug resistance situation and complicated mechanism and multiple-resistance of PA ,we think highly of monitoring and controlling of IRPA and pay attention to the occurrence and prevalence of Dan dru~ resistant strains especially.