阿托伐他汀对高血压患者血压与炎症因子的影响

目的探讨阿托伐他汀对高血压患者血压与炎症因子的影响。方法82例高血压患者，随机分为阿托伐他汀治疗组和常规治疗组，另入选正常体检者60名为健康对照组，观察治疗前及治疗6周后血压、血脂及血清高敏C反应蛋白（hs—CRP）浓度和肝功能、肌酸激酶水平的变化。结果①高血压患者hs—CRP水平高于对照组（P〈0．05）；②阿托伐他汀治疗组血压、血脂、hs—CRP水平下降较常规治疗组更明显，差异有统计学意义（P〈0．05）。结论阿托伐他汀可降低高血压患者血压及hs—CRP水平。

Effects of atorvastatin on blood pressure and inflammatory factor in hypertensive patients

Objective To investigate the effect of atorvastatin on blood pressure and inflammatory factors in hypertensive patients. Methods 82 cases of hypertensive patients were randomly divided into atorvastatin treatment group and conventional treatment group, and the other selected 60 patients with normal physical examination were normal control group. Blood pressure,blood lipid and serum high-sensitivity C-reactive protein （hs-CRP） concentration changes were measured before and after treatment of 6 weeks. Results （1）hs-CRP levels in patients with essential hypertension higher than normal controls （P〈0.05）. （2）In atorvastatin treatment group,blood pressure,lipids and hs-CRP levels decreased significantly than the conventional therapy group（P〈0.05）. Conclusion Atorvastatin in hypertensive patients can reduce blood pressure and hs-CRP levels.