慈菇对镉致大鼠脂质过氧化反应干预作用的探讨

为探讨慈菇对镉致大鼠脂质过氧化反应的干预作用，采用纯种Ｗｉｓｔａｒ 大鼠，随机分为６组：正常对照组、镉处理组、阳性对照组、低剂是干预组、中剂量干预组和高剂量干预组，连续观测６ 周。观察血清及肝匀浆脂质过氧化物（ＬＰＯ） 、肝匀浆谷胱甘肽过氧化物酶（ ＧＳＨｐｘ） 、血浆及肝组织镉（Ｃｄ）含量等指标。结果显示中剂量和高剂量干预组的血ＬＰＯ 均比镉处理组明显降低（Ｐ＜ ０－０５） ，而与阳性对照组无差别：３ 个剂量干预组肝组织Ｃｄ 含量均比镉处理组明显降低，高剂量组的肝组织Ｃｄ 与阳性对照组无差别；３ 个剂量干预组肝匀浆ＬＰＯ 与镉处理组及阳性对照组均无明显差别；高剂量干预组的ＧＳＨｐｘ 比镉处理组及阳性对照均明显增高。提示较高剂量的慈菇汁具有拮抗Ｃｄ 致大鼠脂质过氧化反应的作用。

Study on the Intervention Effect of Sagittaria Agittifolia to Lipid Peroxidation in Cd Exposed Rats

In order to investigate the effect of Sagittaria agittifolia on rats lipid peroxidation caused by cadmium(Cd),wistar's rats(devided into 6 groups equal in male and female)was used to experiment with 6 weeks observation.To measure serum and liver lipid peroxide(LPO) concentration,the GSH px activity,the contents of cadmium in liver were determined.The results showed that the serum LPO of middle and high dose of Sagittaria agittifolia treatment groups decreased remarkablely comparing with Cd treatment group.The Cd in liver of three dose of Sagittaria agittifolia treatment groups was also decreased remarkablely comparing with Cd tmatment group,and no difference between high dose of Sagittarittifolia treatment groups and vitamin E treatment groups.The LPO in liver of three dose of Sagittaria agittifolia treatment groups was not remarkable difference comparing with Cd treatment group and vitamin E treatment groups.The GSH px activity of high dose of Sagittaria agittifolia treatment groups was increased remarkablely comparing with Cd treatment group and vitamin E treatment grops.It was suggestd the Intervention effect of Sagittaria agittifolia on rats lipid peroxidation caused by cadmiun.