非那雄胺对良性前列腺增生患者的前列腺体积及PSA的影响

【目的】观察非那雄胺对前列腺体积和前列腺特异性抗原（PSA）的影响。【方法】良性前列腺患者91例，试验组44例服用非那雄胺，对照组47例服用哈乐胶囊，均治疗6个月。观察两组服药前后的PSA、前列腺体积情况。【结果】对照组前列腺体积降低1．7％，PSA降低2．6％，与治疗前比较均无统计学意义（P〉0．05）；试验组前列腺体积降低30．6％，PSA降低31．9％，与治疗前比较差异均有显著性（P〈0．01）。PSA〈4ng／mL中活检诊断为前列腺癌者2例，4ng／mL〈PSA〈10ng／mL中活检诊断为前列腺癌者3例。【结论】非那雄胺能有效降低前列腺体积和PSA。

Effect of Finasteride on Prostate Volume and PSA of Benign Prostatic Hyperplasia

Objective]To observe the effect of finasteride on prostate volume and prostate specific antigen （PSA）. Methods]Totally 91 cases of benign prostatic hyperplasia took finasteride for 6 months. PSA and prostate volume before and after taking medicine were observed. Results] In the control group, the prostate volume decreased 1.7% and PSA decreased 2.60/60, but there was no significant difference（all P 〉0.05）. In the research group, the prostate volume decreased 30.6; and PSA decreased 31.9%, and there were significant differences（all P d0.01）. Two patients with PSA〈4ng/mL were diagnosed as prostate cancer by biopsy. Three patients with 4ng/ml（PSA;10 ng/mL were diagnosed as prostate cancer by biopsy. Conclusion] Finasteride can effectively reduce prostate volume and PSA.