血清胱抑素C测定对糖尿病肾病的早期诊断价值

[目的]探讨血清胱抑素C(Cys-C)对糖尿病肾病(DN)早期的诊断价值.[方法]随机选择86例住院2型糖尿病(T2DM)患者和35例健康体检者作为研究对象,并根据尿微量白蛋白排泄率(UAER)将86例患者分成三组.A组:UAER＜20 μg/min,共38例;B组:UAER 20～200 μg/min,共28例;C组...

Value of the Measurement of Serum Cystatin C in Early Diagnosis of Diabetic Nephropathy

[Objective] To explore the value of the measurement of serum cystatin C in early diagnosis of diabetic nephropathy（DN）. [Methods] Totally 86 inpatients with type 2 diabetes mellitus（T2DM） and 35 normal persons were randomly enrolled in the study. According to urinary albumin excretion rate（UAER）, all the 86 patients were divided into group I（UAER〈20μg/min, n = 38）, group Ⅱ（UAER 20-200 μg/min, i.e. recessive DN, n = 28） and group Ⅲ （UAER〉200 μg/min,i. e. dominant DN, n=20）. Serum Cys-C, Urea, creatinine（Scr） and urine UAER of all research objects were measured by TBA-120FR. [Results] As compared with control group, the changes of serum Cys-C, Urea and Scr in group I were not significant（p〉0.05）. In group Ⅱ, serum Cys-C slightly increased（ P〈0.05）, but the chan ges of Urea and Scr were not significant（ P 〉0.05）. There was significant difference in serum Cys-C between group Ⅲ and control group, group I and group Ⅱ（all P 〈0.01）, but there was no significant difference in Urea and Scr（ P〉 0.05）. With the increasing of UAER, serum Cys-C elevated（ P 〈0.01）. [Conclusion] Serum Cys-C is of great value for early diagnosis of DN.