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| 类风湿关节炎患者转运蛋白基因多态性与甲氨蝶呤疗效及安全性的相关性研究进展 | |
| 引用本文： | 蔡静,徐建华. 类风湿关节炎患者转运蛋白基因多态性与甲氨蝶呤疗效及安全性的相关性研究进展[J]. 中国临床药理学杂志, 2010, 26(3) |
| 作者姓名： | 蔡静 徐建华 |
| 作者单位： | 安徽医科大学附属医院风湿科,合肥,230022 |
| 摘 要： | 甲氨蝶呤是治疗类风湿关节炎应用最广泛的药物之一,其疗效及不良反应个体差异很大.本文介绍了人体甲氨蝶呤转运蛋白的结构和功能,并阐明其基因单核苷酸多态性可能对药物反应的个体差异. |
| 关 键 词： | 甲氨蝶呤 类风湿关节炎 转运蛋白 单核苷酸多态性 |
Research progress of relationship between the single nucleotide polymorphisms of transporters genes and the efficacy and safety of methotrexate in rheumatoid arthritis patients |
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| CAI Jing,XU Jian-hua. Research progress of relationship between the single nucleotide polymorphisms of transporters genes and the efficacy and safety of methotrexate in rheumatoid arthritis patients[J]. The Chinese Journal of Clinical Pharmacology, 2010, 26(3) | |
| Authors: | CAI Jing XU Jian-hua |
| Abstract: | Methotrexate (MTX) is one of the most widely used disease-modifying antirheumatic drug for the treatment of rheumatoid arthritis. Its efficacy and toxicity has significant differences among patients. This arti-cle introduces structures and functions of human MTX transporters, and clarifies their single-nucleotide polymorphisms in genes coding for trans-porters are probably related with differences of drug reactions among pa-tients. |
| Keywords: | methotrexate rheumatoid arthritis transporters single-nucleotide polymorphisms |
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