清开灵抗大鼠谷氨酸神经毒性脑损伤的实验研究 |
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引用本文: | 岳少杰,曾庆善,周建华,陶永光,曾珊,伍赶球,虞佩兰,罗自强.清开灵抗大鼠谷氨酸神经毒性脑损伤的实验研究[J].中国中西医结合杂志,2000,20(11):842-845. |
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作者姓名: | 岳少杰 曾庆善 周建华 陶永光 曾珊 伍赶球 虞佩兰 罗自强 |
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作者单位: | [1]湖南医科大学湘雅医院儿科,长沙 [2]湖南医科大学,长沙 |
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基金项目: | 国家自然科学基金资助课题!(No .3970 0 1 93) |
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摘 要: | 目的:观察清开灵对大鼠谷氨酸神经毒性脑损伤的作用。以寻找有效的抗谷氨酸神经毒性的中西药物。方法:采用细胞形态计量、电镜及免疫组织化学方法,观察清开灵对谷氨酸所致大鼠脑损伤的影响。结果:清开灵可对抗谷氨酸所致的大鼠脑组织水、钠含量的增加,减轻谷氨酸所致的皮层及海马细胞形态结构的损伤,降低脑组织中c-fos阳性细胞率。结论:清开灵具有抗谷氨酸神经毒性作用。其作用机制与抑制谷氨酸所致的c-fos基因表达
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关 键 词: | 谷氨酸 清开灵 实验研究 神经毒性脑损伤 |
Experimental Study of Protective Effect of Qingkailing on Glutamate Induced Neurotoxic Damage of Brain |
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Authors: | YUE Shaojie ZENG Qingshan ZHOU Jianhua |
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Abstract: | Objective: To observe the effect of Qingkailing (QKL) on glutamate induced damage of brain, in order to seek for effective drugs for antagonizing neurotoxicity of glutamate. Methods: Number and morphology metrology of neuron in cerebral cortex and hippocampus were detected by using MIAS 300 image analysing instrument, electron microscope and immunohistochemical methods. Results: QKL could alleviate the glutamate induced accumulation of water and sodium in the brain tissue, relief the damage of cerebral cells and reduce the percentage of c fos positive cell in brain. Conclusion: QKL could protect brain damage induced by glutamate, which might be related to inhibition of QKL on glutamate caused enhancement of c fos gene expression. |
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Keywords: | cerebral damage glutamate Qingkailing electron microscope c-fos gene cell morphological metrology |
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