| 瘦素与多囊卵巢综合征的研究进展 |
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| 引用本文： | 胡敏,侯丽辉,吴效科.瘦素与多囊卵巢综合征的研究进展[J].中国妇幼健康研究,2006,17(2):125-128. |
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| 作者姓名： | 胡敏 侯丽辉 吴效科 |
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| 作者单位： | 黑龙江中医药大学附属第一医院妇产科,黑龙江,哈尔滨,150040 |
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| 摘 要： | 多囊卵巢综合征是一种病因未明的疾病,其临床常见代谢异常的表现,包括超重或肥胖,胰岛素抵抗,糖耐量减低或2型糖尿病,血脂异常和罹患心血管疾病的危险增加.瘦素是一种新型的脂肪源性的肽类激素,其与肥胖、不孕和胰岛素间有着密切的关系.肥胖的多囊卵巢综合征患者瘦素水平改变,瘦素与多囊卵巢综合征的胰岛素抵抗/高胰岛素血症及2型糖尿病间相互影响,多囊卵巢综合征血脂异常及并发心血管疾病的患者瘦素也有变化.所以,瘦素可能参与了多囊卵巢综合征的代谢,引起多囊卵巢综合征代谢异常.
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| 关 键 词： | 多囊卵巢综合征 瘦素 肥胖 胰岛素抵抗 心血管疾病 |
| 文章编号： | 1673-5293（2006）02-0125-04 |
| 收稿时间： | 2006-01-11 |
| 修稿时间： | 2006年1月11日 |
Correlation of leptin with metabolic disturbance of patients with PCOS |
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| HU Min,HOU Li-hui,WU Xiao-ke.Correlation of leptin with metabolic disturbance of patients with PCOS[J].Chinese Journal of Maternal and Child Health Research,2006,17(2):125-128. |
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| Authors: | HU Min HOU Li-hui WU Xiao-ke |
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| Abstract: | PCOS is an etiology unknown disease.The clinical manifestation of metabolic disturbance in PCOS includes overweight or obesity,insulin resistance(IR),impaired glucose tolerance(IGT),type 2 diabetes mellitus(T2DM),lipometabolism disturbance and increased risk of cardiovascular disease.Leptin is a new lipogenic peptide hormone.It is correlated to obesity,infertility and insulin closely.Changes in leptin level are commonly seen in obese patients with PCOS.Leptin interacts to insulin resistance,hyperinsulinemia and T2DM.Moreover,leptin level of the patients with PCOS who have abnormal blood lipids and are complicated with cardiovascular disease changes.Therefore,leptin might take part in the metabolism of PCOS,resulting in metabolic disturbance. |
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| Keywords: | PCOS leptin obesity insulin resistance cardiovascular disease |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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