Radioprotective effect of silymarin against radiation induced hepatotoxicity |
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Authors: | Laila A Ramadan Hamed M Roushdy Gamal M Abu Senna Nour E Amin Ola A El-Deshw |
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Institution: | Department of Drug Radiation Research and Radiation Biology, National Centre For Radiation Research And Technology (NCRRT), Atomic Energy Authority, PO Box 29, Nasr City, Cairo, Egypt. laila_ramadan@hotmail.com |
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Abstract: | The radioprotective effect of silymarin using different modes of treatment against radiation (3 or 6 Gy) induced hepatotoxicity 1, 3 and 7 days post-irradiation was studied. Whole-body gamma-irradiation revealed an increase in serum alkaline phosphatase (AP) activity as well as liver glutathione reductase (GR) and glutathione peroxidase (GSH-PX) activities on the first post-exposure day with respect to the control value. However, 3 days after radiation exposure, these parameters showed a significant decrease below the control level which persisted till the end of the experimental time except for serum AP activity that showed another increase on the seventh post-exposure day at 3 Gy dose of radiation. A gradual increase in serum alanine and aspartate aminotransferase (ALT&AST) as well as gamma glutamyl transpeptidase activities were observed due to irradiation throughout the experimental time. Administration of silymarin as single (70 mg kg (-1)), fractionated (490 mg kg (-1)) oral doses or as intravenous (i.v.) injection (50 mg kg (-1)), caused significant protection. Intravenous treatment showed the most pronounced protection. The protective effect of silymarin was attributed to its antioxidant and free radicals scavenging properties. |
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Keywords: | irradiation silymarin hepatotoxicity |
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