尼莫地平干乳的家兔口服生物利用度研究

目的以尼莫地平为模型药物，对其干乳、脂肪乳、片剂3种制剂的生物利用度进行比较研究。方法新西兰大白兔单次口饲尼莫地平制剂，用HPLC法测定血浆中尼莫地平的浓度，根据血药浓度计算生物利用度。结果兔口饲尼莫地平后，干乳和脂肪乳的生物利用度均大于片剂，差异具有统计学意义；干乳和脂肪乳的生物利用度比较，差异无统计学意义。与片剂相比尼莫地平干乳和脂肪乳均具有一定的缓释作用。结论干乳和脂肪乳能较大地提高尼莫地平兔口服生物利用度，且具有缓释作用。

Studies on the oral bioavailability of the nimodipine dried emulsion in rabbits

Objective To study the oral bioavailability of the nimodipine dried emulsion. Methods HPLC was used to determine the blood concentrations of nimodipine after the dried emulsion, emulsion and tablets of nimodipine were orally administrated to the rabbit respectively. Results The bioavailabilities were ranked as follws ： emulsion 〉 dried emulsion 〉 tablet. The difference of the bioavailabilities between dried emulsion and tablet was significant（ P 〈 0. 05 ）. The difference of the bioavailabilities between emulsion and tablet was also significant（ P 〈 0.05）. The difference of the bioavailabilities between dried emulsion and emulsion was not significant （P 〉 0.05 ）. Conclusion The results showed that the emulsion and dried emulsion of nimodipine could markedly increase the oral absorption of the drug. Conclusion With the nimodipine tablet, the emulsion and dried emulsion have sustained release effect.