| 微小 RNA 与食管鳞状细胞癌 |
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| 引用本文： | 陈俊,李杰. 微小 RNA 与食管鳞状细胞癌[J]. 国际肿瘤学杂志, 2016, 0(11): 858-860. DOI: 10.3760/cma.j.issn.1673-422X.2016.11.015 |
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| 作者姓名： | 陈俊 李杰 |
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| 作者单位： | 山西医科大学附属肿瘤医院放疗胸科一病区, 太原,030013 |
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| 摘 要： | 微小 RNA（miRNA）可通过细胞信号转导、上皮间质转化、血管生成等调控机制影响食管鳞状细胞癌细胞的增殖、凋亡、侵袭和转移。特定的血清 miRNA 可作为食管鳞状细胞癌诊断、预后的新型肿瘤标志物。近来研究表明 miRNA 可提高食管鳞状细胞癌放疗敏感性甚至逆转多药耐药，具有极大的临床价值。
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| 关 键 词： | 微 RNAs 食管肿瘤 |
MicroRNAs and esophageal squamous cell carcinoma |
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| Abstract: | MicroRNAs (miRNAs)can influence the proliferation,apoptosis,invasion and metastasis of esophageal squamous cell carcinoma (ESCC)cells by signal transduction,epithelial-mesenchymal transi-tion,angiogenesis and other regulating mechanisms.Specific serum miRNAs can serve as novel diagnostic and prognostic biomarkers of ESCC.Recent studies have indicated that miRNAs can improve the radiation sensitivi-ty and even reverse multi-drug resistance of ESCC,holding great clinical value. |
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| Keywords: | MicroRNAs Esophageal neoplasms |
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