| 以前列腺特异性膜抗原为靶点的主动靶向载体研究进展 |
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| 引用本文： | 武鑫,朱全刚,王晓宇,高申. 以前列腺特异性膜抗原为靶点的主动靶向载体研究进展[J]. 药学服务与研究, 2011, 11(5): 321-324. DOI: 10.5428/pcar20110501 |
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| 作者姓名： | 武鑫 朱全刚 王晓宇 高申 |
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| 作者单位： | 第二军医大学长海医院药学部,上海,200433 |
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| 基金项目： | 国家自然科学基金(No.30873178,No.81072100) |
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| 摘 要： | 前列腺特异性膜抗原(prostate-specific membrane antigen,PSMA)是一种特异性表达于前列腺恶性实体肿瘤新生毛细血管内皮细胞上的糖蛋白。PSMA是一种较前列腺特异性抗原、前列腺干细胞抗原等更加特异、敏感的肿瘤标志物,在前列腺癌的诊断和靶向治疗中显示出良好的应用前景。但限于相关临床研究的缺乏,要在临床上推广应用PSMA靶向疗法,还需要进行大量的研究以验证其临床安全性、稳定性和有效性等。本文综述了以核苷酸适配体和单克隆抗体作为靶向头基的药物载体治疗前列腺癌的研究进展,并讨论了该领域未来可能的发展方向。
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| 关 键 词： | 前列腺特异性膜抗原 抗原,肿瘤相关,碳水化合物 前列腺癌 载体,靶向 综述 |
Advances in active targeted vectors of prostate-specific membrane antigen for prostate cancer |
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| WU Xin,ZHU QuanGang,WANG XiaoYu,GAO Shen. Advances in active targeted vectors of prostate-specific membrane antigen for prostate cancer[J]. Pharmaceutical Care and Research, 2011, 11(5): 321-324. DOI: 10.5428/pcar20110501 |
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| Authors: | WU Xin ZHU QuanGang WANG XiaoYu GAO Shen |
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| Affiliation: | WU Xin,ZHU QuanGang,WANG XiaoYu,GAO Shen(Department of Pharmacy,Changhai Hospital,Second Military Medical University,Shanghai 200433,China) |
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| Abstract: | Prostate specific membrane antigen(PSMA) is an integral membrane glycoprotein,which is specifically exprssed in the neovascular endothelial cells of prostatic solid tumors.It is more specific and sensitive than prostate specific antigen(PSA) and prostate stem cell antigen(PSCA) and shows a good prospect in diagnosis of prostate cancer and its targeted therapies.However,general clinical application of PSMA-targeted therapies still requires extensive clinical studies to test clinical safety,stability and effi... |
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| Keywords: | prostate-specific membrane antigen antigens tumor-associated carbohydrate prostate cancer carrier target review |
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