血清降钙素原与C反应蛋白联合检测在新生儿感染性疾病中的应用

目的:评价降钙素原(procalcition,PCT)与C反应蛋白(C-reactive protein,CRP)联合检测对新生儿感染性疾病的诊断及病情评估的价值。方法:选择2008-2010年入院的60例细菌性感染的新生儿,分为重症感染组32例和局部感染组28例,检测患儿血清PCT、CRP的含量及动态变化,并与30例非感染组进行比较。结果:重症感染组血清PCT、CRP浓度平均值分别为25.3μg/L和24.3mg/L;局部感染组血清PCT、CRP浓度平均值分别为3.5μg/L和15mg/L,与非感染组相比,差异有统计学意义(P<0.001);经有效的抗菌治疗后,细菌感染组患儿的PCT、CRP浓度均下降,与治疗前相比,差异有统计学意义(P<0.001);PCT的敏感性和CRP相似(93.3%),PCT的特异性(83.3%)高于CRP(63.3%)。结论:PCT、CRP联合检测对新生儿细菌性感染的早期诊断有重要价值,PCT的特异性要优于CRP,动态检测PCT水平有助于评估治疗效果,协助判断疾病的转归。

Application of the Combined Determination of Serum Procalcitionin and C-reactive Protein in Neonate with Infection

Objective：To evaluate the clinical value of the combined determination of serum procalcitonin（PCT）and C reactive protein（CRP）in the diagnosis and curative effect in neonate with infection.Methods：60 infants in our hospital from 2008 to 2010 with bacterial infection were enrolled in the study which were classified into serious infection group and local infection group.Serum PCT and CRP levels and their dynamic change were measured,and the results were analyzed and compared with those of non-infection group.Results：The mean value of PCT and CRP concentrations in serious infection group were 25.3μg/L and 24.3mg/L.In local infection group,the mean value were 3.5μg/L and 15mg/L respectively,and there were statistical significance compared to non-infection group（P0.001,0.001）;After the antibiotic treatment,the levels of PCT and CRP decreased significantly（P0.001）;The sensitivity of PCT was similar with that of CRP（93.3%）,the specificity of PCT（83.3%）was better than that of CPR（63.3%）.Conclusion：The conbined determination of PCT and CRP assists the early diagnosis and prognosis of bacterial infection in neonate.The specificity of PCT was better than that of CRP.Monitoring dynamically PCT level will help to evaluate the curative effect.