Interleukin-1 inhibits keratan sulfate production by rabbit chondrocytes: Possible role of prostaglandin E2 |
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| Authors: | K Fukuda K Ohtani H Dan S Tanaka |
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| Institution: | (1) Department of Orthopaedic Surgery, Kinki University School of Medicine, Ohnohigashi 377-2, Osaka-sayama, 589 Osaka, Japan |
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| Abstract: | We investigated the importance of prostaglandin E2 (PGE2) release in interleukin-1 (IL-1)-induced inhibition of aggrecan synthesis by chondrocytes. Keratan sulfate (KS) production was measured in parallel with PGE2 release in chondrocytes. IL-1 inhibited KS production and stimulated PGE2 release. In the presence of PGE2, there was a dosedependent decrease in baseline KS production. Indomethacin and dexamethasone partially blocked the IL-1-induced PGE2 release while KS production recovered. Our results suggest that IL-1 inhibits KS production, in part, by stimulating the release of PGE2. |
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| Keywords: | Aggregan Indomethacin Dexamethasone |
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