褪黑素治疗骨质疏松的研究进展

随着人口老龄化,骨质疏松的发病率越来越高,传统药物治疗多是以防止骨质流失为主要机制,且存在各种不良反应。褪黑素是松果体分泌的吲哚激素,被认为可以调节骨代谢。褪黑素通过激活MT2受体、调节骨代谢指标、抗氧化、调节骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMMSC)等作用增强成骨细胞分化;通过下调核因子-κB(receptor activator of nuclear factor-κB,RANK)受体活化因子配体(receptor activator of nuclear factor-κB ligand,RANKL)、上调降钙素分泌来抑制破骨细胞分化。大量的动物实验及人体试验也证明褪黑素可以改变骨显微结构、调节骨代谢指标、增加骨密度,且几乎没有严重的不良反应。因此,褪黑素被认为在治疗骨质疏松方面有着良好的前景。

Research progress of melatonin in the treatment of osteoporosis

With the aging of the population,the incidence of osteoporosis becomes higher and higher.The main mechanism of traditional drug therapy is to prevent bone loss,which will be accompanied by a variety of adverse reactions.Melatonin,an indole hormone secreted by the pineal gland,can regulate bone metabolism.Melatonin enhances osteoblast differentiation by activating MT2 receptor and regulating bone metabolism,antioxidation,and bone marrow mesenchymal stem cell(BMMSC).Besides,melatonin inhibits osteoclast differentiation by down-regulating nuclear factor-κB(RANK)receptor activating factor ligand(RANKL)and up-regulating calcitonin secretion.In addition,a large number of animal and human experiments have also revealed that melatonin improves bone microstructure,regulates bone metabolic indicators,increases bone mineral density with almost no serious adverse reactions.Thus,melatonin is of great potential in the treatment of osteoporosis.