|
|||||
|
|
| 肠溶包衣材料丙烯酸树脂水分散体的制备 | |
| 引用本文： | 常杰,彭领,付培蕾,孙志强,李金鹏,张绍国,武毅君. 肠溶包衣材料丙烯酸树脂水分散体的制备[J]. 中国药品标准, 2021, 22(2): 146-150 |
| 作者姓名： | 常杰 彭领 付培蕾 孙志强 李金鹏 张绍国 武毅君 |
| 作者单位： | 河南大学药学院;连云港万泰医药材料有限公司 |
| 基金项目： | 河南大学2020年度大学生创新训练计划项目,基于一致性评价的奥美拉唑肠溶包衣辅料研究(项目编号:S202010475003)。 |
| 摘 要： | 目的:制备肠溶包衣材料甲基丙烯酸-丙烯酸乙酯水分散体.方法:通过单因素考察法确定最佳制备工艺.结果:最佳工艺为:聚合温度为75～80℃,在聚合过程中缓慢滴加单体的加料方式,使用复配乳化剂SDS及吐温80,0.3％的引发剂过硫酸铵,0.65％的分子量调节剂十二烷基硫醇.结论:根据最佳工艺制备的丙烯酸树脂符合药典规定,性能... |
| 关 键 词： | 丙烯酸树脂 最佳工艺 肠溶包衣材料 |
Preparation of acrylic resin aqueous dispersion of enteric coating material |
|
| CHANG Jie,PENG Ling,FU Peilei,SUN Zhiqiang,LI Jinpeng,ZHANG Shaoguo,WU Yijun. Preparation of acrylic resin aqueous dispersion of enteric coating material[J]. , 2021, 22(2): 146-150 | |
| Authors: | CHANG Jie PENG Ling FU Peilei SUN Zhiqiang LI Jinpeng ZHANG Shaoguo WU Yijun |
| Affiliation: | (College of Pharmacy of Henan University,Kaifeng 475004,China;Lianyungang Wantai Medical Materials Co.,Ltd.,Lianyungang Jiangsu 222069,China) |
| Abstract: | Objective:To prepare enteric coating material methacrylic acid-ethyl acrylate aqueous dispersion.Methods:The best preparation process was determined by single factor investigation.Results:The best process was as follows:the polymerization temperature was 75-80℃,the monomer was slowly added in the polymerization process,the compound emulsifier SDS and Tween 80 were used,the initiator ammonium persulfate was 0.3%,and the molecular weight regulator dodecyl mercaptan was 0.65%.Conclusion:The acrylic resin prepared according to the optimum process accords with the provisions of Pharmacopoeia,the performance is the same as that of imported products,and the molecular weight is moderate,so it is suitable for enteric-coated drug coating. |
| Keywords: | acrylic resin optimum process enteric coating material |
| 本文献已被 维普 等数据库收录！ | |
| 点击此处可从《中国药品标准》浏览原始摘要信息 | |
| 点击此处可从《中国药品标准》下载全文 | |