血清VIP水平与老年人群骨密度及肌肉减少症相关性研究

目的探索血管活性肠肽(vasoactive intestinal peptide,VIP)水平与老年人群骨密度和肌肉减少症相关性。方法受试者包括216名成年人(79名男性和137名女性;平均年龄73.5岁)接受全面体检。检测所有受试者骨骼肌指数(SMI)、腰椎(L1-L4)和股骨颈骨密度和步行速度,符合亚洲肌肉减少症工作组标准的受试者被分配到肌肉减少症组。仅肌肉量减少的受试者被分配到肌量减少组,其他受试者分配到正常组。Oswestry功能障碍指数(ODI)和腰痛视觉模拟评分(VAS)用于评估腰痛。同时检测血清VIP水平;对三组之间肌肉减少症决定因素如骨密度、VAS和VIP等数据进行统计学分析。结果12名受试者(5.5%)患有肌肉减少症。肌肉减少症组的平均ODI评分显著高于肌量减少组和正常组分别为(25.2±12.3)%、(11.2±10.0)%和(11.9±12.3)%,P<0.05]。肌肉减少症组血清VIP水平显著低于肌量减少组和正常组(P<0.05)。肌肉减少症组的腰椎(L1-L4)和股骨颈骨密度和BMI显著低于其他组(P<0.05)。腰椎(L1-L4)和股骨颈骨密度及步行速度、ODI与血清VIP水平之间存在正相关(P<0.05)。结论老年人群中肌肉减少症及腰椎(L1-L4)和股骨颈骨密度、腰痛与血清VIP水平密切相关。

Correlation between serum VIP levels and bone mineral density and sarcopenia in the elderly

Objective To explore the correlation between vasoactive intestinal peptide (VIP) levels and bone mineral density (BMD) and sarcopenia in the elderly. Methods The subjects included 216 adults (79 men and 137 women; mean age, 73.5 years) undergoing a general medical examination. Skeletal muscle index (SMI), BMD of the lumbar spine (L1-L4) and femoral neck, and walking speed were measured. Subjects who met the criteria of the Asian Working Group for Sarcopenia were assigned to the sarcopenia group. Subjects with decreased muscle mass only were assigned to the pre-sarcopenia group. All other subjects were assigned to the normal group. The Oswestry disability index (ODI) and the low back pain visual analogue scale (VAS) were used as indices of low back pain. serum VIP levels were detected simultaneously. Sarcopenia determining factors, such as BMD, VAS, and VIP, were statistical analyzed. Results Twelve subjects (5.5%) had sarcopenia. The average ODI score in the sarcopenia group (25.2%±12.3%; P<0.05) was significantly higher than that in the muscle loss group (11.2%±10.0%) and the normal group (11.9% ±12.3%). The level of serum VIP in sarcopenia group was significantly lower than that in muscle loss group and normal group (P<0.05). BMD of the lumbar spine (L1-L4) and femoral neck and BMI in the sarcopenia group was significantly lower than that in the other groups (P<0.05). There was a positive correlation between lumbar spine (L1-L4) and femoral neck BMD and walking speed, ODI and serum VIP levels (all P<0.05). Conclusion The results of this study indicate that sarcopenia, lumbar spine (L1-L4) and femoral neck BMD, and low back pain are closely correlated to serum VIP levels in the elderly.