脂肪细胞因子与绝经后骨质疏松相关性的Meta分析

目的通过Meta分析对脂肪细胞因子(Adipocytokines)与绝经后骨质疏松(postmenopausal osteoporosis,PMOP)发生率的相关性进行系统评价。方法检索CNKI、CBM、维普、万方、PubMed、Web of Science、EMBASE、Cochrane Library等中英文数据库有关脂肪细胞因子(瘦素、脂联素、抵抗素)与PMOP相关性的病例对照研究和队列研究,设定文献发表时间为各数据库建库至2020年1月30日。以NOS评分量表严格对文献进行质量评价,并准确提取相关文献信息与数据,应用Revman5.3进行Meta分析和制作漏斗图。结果共纳入14篇病例对照研究,包括1094例研究对象,其中PMOP组615例,对照组479例。Meta分析结果显示:PMOP组瘦素含量低于对照组MD=-1.58,95%CI(-3.05,-0.11),P=0.03],PMOP组脂联素含量高于对照组MD=3.41,95%CI(0.84,5.99),P=0.009],PMOP组抵抗素含量高于对照组MD=0.73,95%CI(0.24,1.21),P=0.003]。结论在绝经后女性中,瘦素低含量、脂联素和抵抗素高含量的人群存在PMOP的可能性更高,而基于瘦素低含量、脂联素高含量时反映BMI水平降低,从而推测绝经后女性BMI水平可能与PMOP发生率呈负相关。

Association between adipocytokines and postmenopausal osteoporosis: a Meta-analysis

Objective To explore the association between adipocytokines and postmenopausal osteoporosis (PMOP) with systematical evaluation. Methods The case-control studies and the cohort studies about the association between adipocytokines (leptin, adiponectin, and resistin) and PMOP were retrieved from CNKI, CBM, Chinese Science and Technique Journals Database, Wanfang database, the Cochrane Library, PubMed, Web of Science, and EMBASE during the time from the establishment of database to 30 January 2020. The quality was assessed according to the Newcastle Ottawa Scale. The information and data of research were accurately extracted. System evaluation, meta-analysis, and funnel plots were conducted with a RevMan 5.3 software. Results A total of 14 case control studies were involved, including 1094 individuals. Among them, 615 were in PMOP group and 479 were in control group. Meta-analysis results showed that: leptin (MD= -1.58, 95% CI: -3.05 to -0.11, P=0.03) in PMOP group was lower than that in the control group, and adiponectin (MD=3.41, 95% CI: 0.84 to 5.99, P=0.009) and resistin (MD=0.73, 95% CI: 0.24 to 1.21, P=0.003) were higher than those in the control group. Conclusion Postmenopausal women with low leptin, high adiponectin, or high adiponectin are more likely to suffer from osteoporosis. Low leptin and high adiponectin reflect a decrease in BMI. It is suggested that the incidence of PMOP may be negatively correlated with BMI in postmenopausal women.