Risk for the occupational infection by cytomegalovirus among health-care workers |
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| Institution: | 1. Division of Infection Control and Prevention, Osaka University Hospital, Japan;2. Laboratory for Clinical Investigation, Osaka University Hospital, Japan;3. Department of Biomedical Informatics, Osaka University Graduate School of Medicine, Osaka, Japan;4. Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;1. Department of Uro-Oncology, Saitama Medical University International Medical Center, Hidaka, Japan;2. Department of Urology, National Defense Medical College, Tokorozawa, Japan;3. Department of Urology, Saiseikai Central Hospital, Tokyo, Japan;4. Department of Urology, Keio University School of Medicine, Tokyo, Japan;5. Department of Urology, Ichikawa General Hospital, Tokyo Dental College, Ichikawa, Japan;6. Department of Urology, Aichi Medical University School of Medicine, Nagakute, Japan;7. Division of Diagnostic Pathology, Keio University Hospital, Tokyo, Japan;8. Department of Urology, National Hospital Organization Saitama Hospital, Wako, Japan;9. Department of Urology, Saitama City Hospital, Saitama, Japan;1. Department of Infection Control and Prevention, Medical Hospital, Tokyo Medical and Dental University, Tokyo, Japan;2. Department of Molecular Microbiology, Tokyo Medical and Dental University, Tokyo, Japan;3. Oral Microbiome Center, Kagawa, Japan;4. Department of Clinical Laboratory, Medical Hospital, Tokyo Medical and Dental University, Tokyo, Japan;1. Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA;2. Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA;3. Department of HIV and Global Hepatitis Programme, World Health Organization, Geneva, Switzerland;1. Department of Radiology, Keio University School of Medicine, Tokyo, Japan;2. Department of Radiology, Tokyo Medical Center, National Hospital Organization, Tokyo, Japan;3. Department of Urology, Tokyo Medical Center, National Hospital Organization, Tokyo, Japan |
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| Abstract: | BackgroundCytomegalovirus (CMV) are ubiquitously distributed worldwide, causing a wide range of clinical manifestations from congenital infection to a life-threatening disease in immunocompromised individuals. CMV can be transmitted via human-to-human contact through body fluids; however, the risk of CMV infection among healthcare workers (HCWs) has not been fully evaluated.AimThis study aimed to assess the risk of CMV infection among HCWs through daily medical practices.MethodsSerum samples from HCWs at Osaka University Hospital (Japan) were analysed. Initially, we compared CMV IgG seropositivity among HCWs (medical doctors, nurses, and others) in 2017, which was examined after 1 year to evaluate seroconversion rates among those with seronegative results. Then, we examined CMV seroconversion rates in HCWs who were exposed to blood and body fluids.FindingsWe analysed 1153 samples of HCWs (386 medical doctors, 468 nurses, and 299 others), of which CMV seropositivity rates were not significantly different (68.9%, 70.3%, and 70.9%, respectively). Of these, 63.9% (221/346) of CMV seronegative HCWs were followed after 1 year, with CMV seroconversion rates of 3.2% (7/221). Among 72 HCWs who tested negative for CMV IgG when exposed to blood and body fluids, the CMV seroconversion rate was 2.8% (2/72). The CMV seroconversion rates between the two situations were not significantly different.ConclusionOur study indicated that CMV infection through daily patient care seems quite rare. Further well-designed studies with a large sample size are warranted to verify our finding. |
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| Keywords: | Blood and body fluid exposure Cytomegalovirus Healthcare workers Occupational infection Seroconversion |
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