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| 慢性特发性荨麻疹患者外周血单个核细胞分泌IFN-γ和IL-4水平检测及意义 | |
| 引用本文： | 孙仁山,陈晓红,冉新泽,程天民,刘荣卿. 慢性特发性荨麻疹患者外周血单个核细胞分泌IFN-γ和IL-4水平检测及意义[J]. 中国皮肤性病学杂志, 2005, 19(3): 149-150 |
| 作者姓名： | 孙仁山 陈晓红 冉新泽 程天民 刘荣卿 |
| 作者单位： | 第三军医大学创伤烧伤与复合伤国家重点实验室防原教研室,重庆,400038 |
| 基金项目： | 重庆市院士基金(995691) |
| 摘 要： | 目的 探讨Th1 /Th2细胞因子水平变化在慢性特发性荨麻疹(CIU)发病机制中的作用。方法 采用ELISA法检测37例CIU患者外周血单个核细胞(PBMC)培养上清中的细胞因子IFN γ和IL 4。结果 CIU患者IFN γ水平低于正常对照组(P<0. 05),其浓度分别为170. 58±230. 28pg/ml及340. 76±220. 35pg/ml;CIU患者IL 4水平高于正常对照组(P<0. 05),其浓度分别为41. 53±12. 57pg/ml与27. 01±13. 54pg/ml。结论 Th2细胞功能亢进及Th1功能低下在CIU发生发展中可能发挥一定的作用。 |
| 关 键 词： | 荨麻疹 Th1细胞 Th2细胞 |
| 文章编号： | 1001-7089(2005)03-0149-02 |
Investigation of PBMC-secreted IFN-γ and IL-4 in Patients with Chronic Idiopathic Urticaria |
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| SUN Ren shan,CHEN Xiao hong,RAN Xin ze,et al. Investigation of PBMC-secreted IFN-γ and IL-4 in Patients with Chronic Idiopathic Urticaria[J]. The Chinese Journal of Dermatovenereology, 2005, 19(3): 149-150 | |
| Authors: | SUN Ren shan CHEN Xiao hong RAN Xin ze et al |
| Abstract: | Objective To explore the role of Th1/Th2 cytokines levels in pathogenesis of chronic idiopathic urticaria (CIU).Methods Peripheral blood of CIU patients was collected and PBMC were separated. ELISA was applied to detect cytokines IFN γ and IL 4 from supernatants of PBMC culture.Results Cytokines IFN γ significantly lower in CIU patients compared with that of normal controls ( P <0.05), the concentration was 170.58±230.28 pg/ml and 340.76±220.35 pg/ml respectively. While cytokines IL 4 increased in CIU patients compared with that of normal controls ( P <0.05), the concentration was 41.53±12.57 pg/ml and 27.01±13.54 pg/ml respectively.Conclusion Increased Th2 function and decreased Th1 function play an important role in the development of CIU. |
| Keywords: | Urticaria Th1 cells Th2 cells |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |