| 帕金森病小鼠相关脑区内钙结合蛋白D28k mRNA的表达 |
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| 引用本文： | 王连刚,王喜青,武毅军,武胜昔,冯幼启. 帕金森病小鼠相关脑区内钙结合蛋白D28k mRNA的表达[J]. 医学争鸣, 2001, 22(3): 259-261 |
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| 作者姓名： | 王连刚 王喜青 武毅军 武胜昔 冯幼启 |
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| 作者单位： | 第四军医大学西京医院实验外科;第四军医大学2基础部解剖学教研室;第四军医大学西京医院神经内科, |
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| 摘 要： | 目的 研究钙结合蛋白D28k(CaBP)在帕金森病（PD）发病机制中的作用.方法 将1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）按30mg
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| 关 键 词： | 钙结合蛋白D28k 帕金森病 PCR 原位杂交 小鼠 |
| 文章编号： | 1000-2790(2001)03-0259-03 |
| 修稿时间： | 1999-10-25 |
Expression of calbindin-D28k mRNA in related brain regions of Parkinson's disease in mice |
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| WANG Lian-Gang. Expression of calbindin-D28k mRNA in related brain regions of Parkinson's disease in mice[J]. Negative, 2001, 22(3): 259-261 |
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| Authors: | WANG Lian-Gang |
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| Abstract: | AIM To study the possible role of Calbindin D28k (CaBP) in the pathogenesis of Parkinson's disease (PD). METHODS 1 methyl 4 phenyl 1, 2, 3, 6 tetrahydropyridine (MPTP) was intraperitoneally injected into C57BL mice to establish PD mice model. Reverse transcription PCR and in situ hybridization were used to detect the expression changes of CaBP mRNA in the brain of PD and control mice. RESULTS Compared to control mice, there was a significant decrease in CaBP mRNA levels in hippocampus,striatum and substantia nigra in PD mice. CONCLUSION CaBP may play a protective role for some neurons against the pathogenesis process responsible for PD. |
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| Keywords: | Calbindin D28k Parkinson's disease PCR in situ hybridization mouse |
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