结肠癌术后肝转移经肝动脉栓塞及经皮下药盒腹主动脉灌注化疗疗效观察

目的通过联合应用肝动脉栓塞及经皮下药盒行腹主动脉持续灌注化疗,探讨结肠癌术后肝转移的介入治疗疗效。方法7例结肠癌肝转移患者,其原发病灶均已作根除术,采用Seldinger法经股动脉穿刺插管后行肝动脉栓塞,同时经股动脉植入导管药盒系统(PCS),导管远端置入腹主动脉腹腔动脉开口上一个椎体水平处,3周后经PCS行灌注化疗。每3~4周经PCS重复灌注化疗1次。所有病例跟踪随访1~12月。结果近期疗效以CT检查作为主要评价依据,其中5例有效(完全+部分缓解),总有效率为71.4%。本组患者主要不良反应不同程度肝功能损害、发热及胃肠道反应等,经相应对症处理后缓解。结论肝动脉栓塞联合腹主动脉持续灌注化疗治疗结肠癌术后肝转移,是一种安全有效的方法。

Combination of hepatic arterial chemoembolization and continuous abdominal aorta infusion chemotherapy by PCS for patients with liver metastasis from colorectal cancer

Objective To evaluate the efficacy of hepatic arterial chemoembolization and continuous abdominal aorta infusion chemotherapy for patients with liver metastasis from colorectal cancer.Methods 7 patients with nonresectable liver metastases from colorectal cancer had been treated with radical operation, all patients were treated with combined hepatic artery chemoembolization with continuous abdominal aorta infusion chemotherapy. The PCS was performed after 3 weeks,henceforth per3-4 weeks repeated.All patients were followed-up for 1～12 month. The efficacy of all patients were evaluated by CT.Results An overall response rate(CR+PR) of the cases was 71.4%,the rate(NC and PD)was 14.3%,the survival rate in 1 year was 85.7%.The primary side-effect were liver function injury,fever and digest tract reaction and so on, and these symptoms could be subside.Conclusion The combination of hepatic arterial chemoembolization and continuous abdominal aorta infusion chemotherapy by PCS may be a safe and effective method for patients with liver metastasis from colorectal cancer.