p53 is an independent pre-treatment markers for long-term survival in stage II and III colorectal cancers: an analysis of interaction between genetic markers and fluorouracil-based adjuvant therapy |
| |
Authors: | Tang Reiping Wang Jeng-Yi Fan Chung-Wei Tsao Kuo-Chien Chen Hong-Hua Wu Chi-Ming Chen Jinn-Shiun Changchien Chung Rong Hsieh Ling-Ling |
| |
Affiliation: | Department of Colorectal Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC. |
| |
Abstract: | One hundred and thirty-eight stage II and III colorectal cancer patients were included to evaluate the prognostic significance of genetic markers (including mutations of the p53, K-ras genes, and microsatellite instability) on the response to 5-fluorouracil (FU)-based post-operative adjuvant therapies (PAT). When stratified by PAT and adjusting for other prognostic variables, presence of p53 mutation was associated with a poor outcome (hazard ratio (HR)=3.1, 95% confidence interval (CI), 0.9-11.0) among patients without PAT. Our data confirmed that p53 mutation is an independent pre-treatment factor in stage II and III colorectal cancer after curative resection. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|