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| 维甲酸致小鼠骨质疏松模型的骨组织计量学研究 | |
| 引用本文： | 张军生,戴晨琳,张鑫,邱明才. 维甲酸致小鼠骨质疏松模型的骨组织计量学研究[J]. 天津医药, 2002, 30(8): 481-482 |
| 作者姓名： | 张军生 戴晨琳 张鑫 邱明才 |
| 作者单位： | 1. 300074,天津国际SOS紧急救援诊所 2. 天津医科大学总医院内分泌科 |
| 摘 要： | 目的：建立一种简便易行耗时较少的小鼠骨质疏松模型。方法：将20只小鼠随机分成对照组和维甲酸灌胃组，2周后处死小鼠，利用骨组织计量学方法研究维甲酸对小鼠胫骨的影响。结果：给药组小鼠小梁骨体积明显减少。小梁板厚度减少，且空间结构也发生改变。结论：维甲酸可用于建立小鼠骨质疏松模型。 |
| 关 键 词： | 骨组织计量学 维甲酸 骨质疏松 动物模型 |
A Quantitative Bone Histomorphometry in Mouse Osteoporosis Model Induced by Retinoic Acid |
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| ZHANG Junsheng,DAI Chenlin,ZHANG Xin,et al Tianjin International SOS Clinic,China. A Quantitative Bone Histomorphometry in Mouse Osteoporosis Model Induced by Retinoic Acid[J]. Tianjin Medical Journal, 2002, 30(8): 481-482 | |
| Authors: | ZHANG Junsheng DAI Chenlin ZHANG Xin et al Tianjin International SOS Clinic China |
| Affiliation: | ZHANG Junsheng,DAI Chenlin,ZHANG Xin,et al Tianjin International SOS Clinic,China 300074 |
| Abstract: | Objective: To find a simple and convenient method to establish a mouse osteoporosis model. Methods: Twenty Kunming mice were randomly divided into two groups: control group and treatment group.The mice in the treatment group were given retinoic acid for two weeks, and then were euthanized. The bone section of tibia was decalcified, and the quantitative bone histomorphometry was performed. Results: The significant pathological changes were found in the bone tissue microstructure such as the trabecular volume, and the thickness of trabecular significantly decreased.Conclusion: The mice osteoporosis model was successfully established induced by retinoic acid. |
| Keywords: | tretinoin osteoporosis disease models animal |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |