Plasma lipids in patients with chronic glomerulonephritis

The author examined 78 patients with chronic glomerulonephritis and verified their diagnosis on the basis of the kidney biopsy data. With regard to the severity of the tubular interstitial component the patients were enrolled in three groups. It was stated that with the increasing changes developed in the tubular interstitial component, the levels of total cholesterol, cholesterol of high density lipoproteins, low density lipoproteins and triglyceride elevated. In the group of the patients with minimal changes in the tubular interstitial component, the number of those in whom plasma lipid levels were below the upper normal limits was higher than in two other groups. A direct proportional relationship between the levels of plasma lipids and severity of the tubular interstitial component indicated the immediate role of the renal tissue in the pathogenesis of lipid turnover disorders in patients with chronic glomerulonephritis.