NT－proBNP和Hcy检测在老年急性脑梗死患者中的临床意义

目的：探讨NT－proBNP 和Hcy检测在急性脑梗死患者中的临床意义。方法：选择92例急性脑梗死患者为脑梗死组。按照梗死大小体积分为三个亚组，其中大梗死组(>40cm3)33例、中梗死组(15~40cm3)30例、小梗死组(<15cm3)29例。按病程分为三个亚组，其中急性期组(发病3d内)19例、亚急性期组(发病3~10d内)27例、慢性期组(发病大于10d)46例，另外选择100例健康对照组。比较各组血清NT－proBNP 和Hcy水平的检测结果。结果：脑梗死组患者血清Hcy、NT－proBNP 水平显著高于对照组。大梗死组血清Hcy、NT－proBNP 水平显著高于中、小梗死组。急性期组血清Hcy、NT－proBNP水平显著高于亚急性期组和慢性期组。结论：老年急性脑梗死患者血清NT－proBNP、Hcy水平显著上升，升高程度与梗死体积和发病时间密切相关，值得临床运用。

The Clinical Significance of NT-proBNP and Hcy in Elderly Patients with Acute Cerebral Infarction

Objective:To investigate the clinical significance of NT-proBNP and Hcy in elderly pa-tients with acute cerebral infarction. Methods:92 cases of acute cerebral infarction were collected for cerebral infarction group. According to infarct volume size, they were divided into three subgroups, including large in-farction (> 40 cm3 ) 33 cases, mediate infarction ( 15 cm3~ 40 cm3 ) 30 cases, and small infarction (<15cm3 ) 29 cases. According to the course, they were divided into three subgroups, including acute group ( onset within 3 days) 19 cases, subacute phase group ( incidence of 3 to 10 days) 27 cases, chronic group ( incidence of greater than 10 days) 46 cases. 100 healthy people were selected for control group. The serum levels of NT-proBNP and Hcy test results were compared. Results: Serum Hcy, NT-proBNP levels in pa-tients with cerebral infarction were significantly higher than those in control group. Serum Hcy, NT-proBNP levels in large infarction group were significantly higher than those in small infarction group. Serum Hcy, NT-proBNP levels in acute phase group were significantly higher than those in the subacute phase group and chro-nic phase group. Conclusion: Serum NT-proBNP Hcy levels have a significant increasing in the elderly pa-tients with acute cerebral infarction, in which increased infarct volume is closely related to the degree and time of onset, which is worthy of clinical use.