利伐沙班对老年股骨粗隆间骨折股骨头置换术后DVT发生的影响研究

目的：：探讨利伐沙班在老年股骨粗隆间骨折股骨头置换术后DVT发生影响。方法：42例采用骨水泥型长柄双极股骨头置换术进行治疗的股骨粗隆间骨折患者,随机分为对照组( n＝21)和观察组( n＝21),分别于术后给予低分子肝素钙和利伐沙班,对比两组患者术前、术后凝血功能指标,记录发生下肢深静脉血栓的情况。结果：两组患者术前和术后14d凝血功能指标无统计学意义( P>0.05)；观察组患者的下肢深静脉发生率显著低于对照组(9.5％VS38.1％),差异具有统计学意义(χ2＝22.208,P<0.05)。结论：老年股骨粗隆间骨折患者在股骨头置换术后应用利伐沙班有利于术后下肢深静脉血栓的预防。

The Clinical Study of Rivaroxaban on the Occurance of DVT after Femoral Head Replacement for Femoral Intertrochanteric Fracture in Elderly

Objective:To explore the rivaroxaban on the occurance of DVT after femoral head replace-ment of femoral intertrochanteric fracture in elderly. Methods: 42 cases of intertrochanteric fracture patients received bone cement bipolar artificial femoral head replacement. The patients were randomly divided into con-trol group (n=21)and observation group(n=21).After operation, the patients were randomized to receive low molecular weight heparin ( control group) and rivaroxaban ( observation group ) to prevent DVT. The DVT rate and coagulation function were observed. Results: There was no significant difference in coagulation function between two groups(P>0.05). The DVT rate of observation group were lower than that in control group (9.5%VS38.1%) . There was significant difference between two groups( P<0.05) . Conclusion:Rivaroxaban can be effective in preventing DVT after femoral head replacement for femoral intertrochanteric fracture in elderly.