线粒体跨细胞转运参与中枢神经系统疾病研究进展

线粒体是细胞氧化磷酸化及合成ATP的主要场所,在维持钙稳态、调节活性氧自由基产生、能量平衡与代谢、诱导程序性细胞死亡中均发挥重要作用。越来越多的证据提示线粒体可在细胞间发生转移,对机体产生保护或有害的影响。多种转运方式介导线粒体的跨细胞转运,然而深入的转运机制仍未完全阐明。目前发现线粒体跨细胞转运在多种中枢神经系统疾病损伤修复中具有重要意义。文章主要就线粒体功能、线粒体跨细胞转运及其转运机制、线粒体跨细胞转运与中枢神经系统疾病进行概述。

Advances in intercellular transfer of mitochondria involved in central nervous system diseases

Mitochondria is the main site for oxidative phosphorylation and synthesis of ATP.It plays an important role in maintaining calcium homeostasis,regulating the production of reactive oxygen species,maintaining energy balance and metabolism and inducing programmed cell death.There is increasing evidence that mitochondria can transfer between cells,having protective or harmful effects on the body.Multiple modes have been found to mediate mitochondrial transfer.However,the underlying mechanism is still not fully elucidated.It has been found that mitochondrial transfer plays a significant role in the recovery of various central nervous system diseases.In this review,a brief summary that will be presented on mitochondrial function,mitochondrial transfer and its mechanism,and advances in mitochondrial transfer involved in central nervous system diseases.