常用糖尿病肾病动物模型研究概述

糖尿病肾病是糖尿病进展到晚期阶段的一种微血管并发症,大约有20%~40%的糖尿病患者晚期会进展为糖尿病肾病。在全世界范围内,糖尿病肾病已经成为终末期肾脏病的主要原因。动物模型是研究糖尿病肾病发病机制和治疗方法的良好工具。目前常用的糖尿病肾病模型,都在病理生理上不同程度地模拟了人类糖尿病肾病的部分特征。但糖尿病肾病的研究并未取得可观的进展,其阻碍主要是目前尚无能够完全模拟人类糖尿病肾病所有特征的有效动物模型。本文主要从造模机制、病理生理、优缺点等方面出发,对目前常用的糖尿病肾病动物模型作一综述。

An overview of animal models of diabetic nephropathy

Diabetic nephropathy is a microvascular complication in the advanced stage of diabetes.About 20%-40%of patients with diabetes will progress to diabetic nephropathy.And worldwide,diabetic nephropathy has become the leading cause of end-stage renal disease.Animal model is a useful tool to study the pathogenesis and treatment of diabetic nephropathy.Currently,the commonly used diabetic nephropathy models all simulate partial characteristics of human diabetic nephropathy in different degrees of pathophysiology.However,the research on diabetic nephropathy has not achieved considerable progress.The main obstacle is that there is no effective animal model that can fully simulate all the characteristics of human diabetic nephropathy.In this paper,the animal models of diabetic nephropathy were reviewed from the aspects of modeling mechanism,pathophysiology,their advantages and disadvantages.