Antipseudomonal activity and nephrotoxicity of cephradine-netilmicin combination |
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Authors: | M A El Emam W A El Naggar T M Ibrahiem |
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Institution: | 1. Department of Microbiology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt 2. Department of Pharmacology & Biochemistry Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
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Abstract: | The effects of intraperitoneal injections of cephradine in a dose of 75 mg/kg and netilmicin in dose of 50 mg/kg and their
combination on creatinine and urea serum levels of rabbits were studied as well as the antipseudomonal activity against three
multiresistant clinicial isolates. The antibacterial activity was investigated by two methods: Checkerboard titration method
and time-kill studies. Finally, the antibacterial activity of the sera obtained from the rabbits receiving the used drugs
in the previous regimen was studied using time-kill study method againstPseudomonas aeruginosa isolates. Results obtained from this study indicated that both creatinine and urea serum levels of the rabbits receiving
both drugs were not significantly different from those of the rabbits receiving either cephradine or netilmicin alone. At
the same time thein vitro antibactrial activity (either of the prepared solutions of the used drugs and their combination or of the sera obtained from
the rabbits receiving these drugs as mentioned before) showed a synergistic effect against the tested strains ofPseudomonas aeruginosa |
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Keywords: | Antimicrobial activity nephrotoxicity Pseudomonas aeruginosa cephradine nitromicin synergism |
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