| 异烟肼、利福平治疗肺结核致肝毒性易感基因的研究 |
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| 引用本文： | 王金河,刘金伟,吴雪琼,王心静,张翠英,王安生,仲斌,裴宁.异烟肼、利福平治疗肺结核致肝毒性易感基因的研究[J].军医进修学院学报,2004,25(3):239-240. |
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| 作者姓名： | 王金河 刘金伟 吴雪琼 王心静 张翠英 王安生 仲斌 裴宁 |
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| 作者单位： | 解放军总医院,第309临床部结核病中心,北京,100091 |
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| 摘 要： | 目的：探讨N-乙酰基转移酶(NAT2)基因型与异烟肼、利福平治疗肺结核致肝毒性的相关性。方法：通过聚合酶链反应-限制性片段长度多态性(PCR—RFLP)技术分析67例经利福平、异烟肼治疗后发生或未发生肝功能异常的肺结核患者NAT2基因多态性的部位、性质及发生率。结果：病例组和对照组857位密码子多态性分别是20．3％和7．1％，两组差异显著。结论：NAT2基因型与异烟肼和利福平所致肝毒性关系密切，其中857位密码子点突变可能是结核患者发生肝毒性的易感基因型之一。
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| 关 键 词： | 异烟肼 利福平 药物治疗 肺结核 肝毒性 易感基因 |
| 文章编号： | 1005-1139(2004)03-0239-02 |
| 修稿时间： | 2003年12月28 |
The study on the susceptible gene of isoniazid and rifampicin-induced hepatotoxicity of pulmonary tuberculosis patients |
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| WANG Jin-he,LIU Jin-wei,WU Xue-qiong,WANG Xin-jing,ZHANG Cui-ying,WANG An-sheng,ZHONG Bin,PEI Ning.The study on the susceptible gene of isoniazid and rifampicin-induced hepatotoxicity of pulmonary tuberculosis patients[J].Academic Journal of Pla Postgraduate Medical School,2004,25(3):239-240. |
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| Authors: | WANG Jin-he LIU Jin-wei WU Xue-qiong WANG Xin-jing ZHANG Cui-ying WANG An-sheng ZHONG Bin PEI Ning |
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| Abstract: | Objective:To investigate the relationship between the susceptibility of isoniazid and rifampicin-induced hepatotoxicity and the N-acetyltransferase 2(NAT2) genotype in the tuberculosis patients.Methods:NAT2 gene was analyzed in 67 pulmonary tuberculosis patients who had normal or abnormal hepatic function by PCR-RFLP.Results:The frequencies of NAT2 gene mutation at codon 857 in patient group and control group were 20.3% and7.1%,respectively,there were significant difference. Conclusion:NAT2 gene mutation at codon 857 might be one of susceptible genotype in the tuberculosis patients whose hepatic functions were abnormal. |
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| Keywords: | rifampin isoniazid hepatitis toxic transferase tuberculosis pulmonary |
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