参附强精汤对肾阳虚型非炎性精液不液化的临床研究

目的:观察自拟参附强精汤治疗肾阳虚型非炎性精液不液化男性不育患者的临床疗效。方法:60例肾阳虚型非炎性精液不液化男性不育症患者,随机分成治疗组(采用参附强精汤口服)30例,对照组(口服维生素C片加糜蛋白酶肌注)30例。两组患者治疗前后分别观察精子活率、精子活力、血清睾酮、精浆PSA及肾阳虚症状改善情况。两组治疗效果按60min内精液液化的状况判断。结果:两组治疗后肾阳虚症状改善结果有显著差异(P<0.01,P<0.05)。治疗组治疗前后、治疗组与对照组治疗后精子活率及活力均有显著差异(P<0.01,P<0.05)。血清睾酮、精浆PSA治疗组治疗前后有非常显著的差异(P<0.01),治疗组与对照组治疗后有显著的差异(P<0.05)。两组治疗效果的总有效率,治疗组为93.3%,对照组为76.7%。两组总疗效比较有统计学差异(P<0.05)。结论:参附强精汤可以改善非炎性精液不液化患者的精液液化时间,使90%以上的患者精液液化恢复至正常水平,同时可缓解低睾酮水平所产生的肾阳虚证的各种症状。

Shenfu Qiangjing Decoction Improves Non-Inflammatory and Non-Liquefied Semen in Kidney-yang Deficiency Men

Objective:To observe the clinical efficacy of Shenfu Qiangjing Decoction(SQD)in the treatment of non-inflammatory and non-liquefied semen in infertile males with kidney-yang deficiency. Methods:Sixty cases of male infertility caused by non-inflamma-tory and non-liquefied semen with kidney-yang deficiency were equally and randomly divided into an SQD and a control group,the for-mer given oral SQD and the latter vitamin C tablets plus intramuscular chymotrypsin.Both groups were observed for sperm viabihty,sperm motility,serum testosterone,seminal plasma PSA and improvement of kidney-yang deficiency symptoms before and after the medication.The therapeutic effects were evaluated according to the semen liquefaction within 60 min. Results:Statistically signifi-cant differences were observed in the improvement of kidney-yang deficiency symptoms after the medication between the SQD and con-trol groups(P<0.01,P<0.05),and in sperm viability and motility of the SQD group before and after the treatment(P<0.01)as well as between the two groups after the medication(P<0.05).The levels of serum T and seminal plasma PSA also showed sig-nificant differences before and after the treatment in the SQD group(P<0.01)and between the two groups after the medication(P<0.05).The rate oftotal effectiveness was 93.3%in the SQD and 76.7% in the control group(P<0.05). Conclusion:SOD can shorten the semen liquefaction time in patients with non-inflammatory and non-liquefied semen and restore semen liquefaction to normal in over 90% of the patients.Meanwhile it can also improve the low testosterone level resulting from various kidney-yang defi-ciency symptoms.