白细胞介素13在系膜增生性肾小球肾炎患者血浆及肾组织的表达

目的 探讨系膜增生性肾小球肾炎(MsPGN)患者血浆及肾组织白细胞介素13(IL—13)的表达，进一步了解MsPGN的分子病理机制，为临床治疗探索新的途径。方法 应用酶联免疫吸附试验(ELISA)和免疫组化ABC技术检测30例MsPGN患者血浆IL—13水平及其在肾组织的表达、定位和分布。结果 MsPGN患者血浆IL—13水平较正常对照组明显增高，以IgAN增高明显MsPGN患者肾小球及肾小管间质区IL—13表达较正常对照组增高，而以肾小管间质区表达更强，non-Iga MsPGN与IgAN相比，肾小管间质区IL—13表达无明显差异。结论 IL—13可能参与了MsPGN分子病理机制。

Expression of Interleukin-13 in Plasma and Renal Tisssue and Their Molecular Pathogenesis in Mesangial Proliferative Glomerulonephritis

Objective The expression of IL-13 in plasma and renal tissue was studied to eluciate the molecular pathogenesis of Mesangial proliferative glomerulonephritis (MsPGN). Methods Plasma level of IL-13 in patients with MsPGN and in normal control groups were examined by ELISA. The expression of IL-13 in patients with MsPGN and in control group were examined by immune histochemistry ABC technique in renal tissue.Results Plasma levels of IL-13 in patients with MsPGN were significantly higher than that in control group,and the highest was found in IgAN;IL-13 expressions in glomerulus and tubulointerstitial zone in patients with MsPGN were higher than that in control group, and IL-13 expression in tubulointerstitial zone was more strong,but it was not distinctive difference between non-IgA MsPGN and IgAN. Conclusion IL-13 may play an important role in the molecular pathogenesis of MsPGN.