急性出血性脑血管病并发多脏器功能失常综合征患者血浆内皮素-1及降钙素基因相关肽水平的观察

目的：探讨血浆内皮素１（ＥＴ１）和降钙素基因相关肽（ＣＧＲＰ）在急性出血性脑血管病（ＡＨＣＶＤ）并发多脏器功能失常综合征（ＭＯＤＳ）发病中的作用。方法：采用放射免疫法分别测定２１例ＡＨＣＶＤ合并ＭＯＤＳ患者（ＭＯＤＳ组）、２０例ＡＨＣＶＤ患者（ＡＨＣＶＤ组）及３０例正常人（正常对照组）血浆中ＥＴ１和ＣＧＲＰ水平。结果：ＭＯＤＳ组及ＡＨＣＶＤ组血浆ＥＴ１水平明显高于正常对照组（Ｐ均＜０．０１），ＭＯＤＳ组ＥＴ１水平又明显高于ＡＨＣＶＤ组（Ｐ＜０．０１）。ＡＨＣＶＤ组血浆ＣＧＲＰ水平高于正常对照组，但无显著性差异（Ｐ＞０．０５）。而ＭＯＤＳ组血浆ＣＧＲＰ水平明显低于正常对照组，ＥＴ１／ＣＧＲＰ（Ｅ／Ｃ）比值明显高于ＡＨＣＶＤ组及正常对照组（Ｐ均＜０．０１）。结论：血浆ＥＴ１水平升高、ＣＧＲＰ水平降低、Ｅ／Ｃ比值严重失衡与ＭＯＤＳ的发生相关；检测血浆ＥＴ１和ＣＧＲＰ水平对评估ＡＨＣＶＤ患者预后有一定意义

Plasma endothelin1 and calcitonin gene related peptide levels in acute hemorrhagic cerebrovascular diseases complicated by multiple organ dysfunction syndrome

Objective:To assess the role of endothelin1 (ET1) and calcitonin gene related peptide (CGRP) in the pathogenesis of acute hemorrhagic cerebrovascular diseases (AHCVD) complicated by multiple organ dysfunction syndrome (MODS).Methods:Plasma ET1 and CGRP levels were examined in 21 AHCVD complicated by MODS (MODS group),20 AHCVD (AHCVD group),and 30 normal volunteers (NV) by radioimmunoassay.Results:Plasma ET1 levels in MODS group and AHCVD group were signif icantly higher than those in the NV (both P <0 01),and they were markedly elevated in MODS group compared to AHCVD group ( P <0 01).Plasma CGRP levels in AHCVD group were increased compared to normal controls without significant difference ( P >0 05),while they were significantly lower in MODS group than NV ( P <0 01).Moreover,ET1/CGRP ratio in MODS group was higher than those in both AHCVD group and NV (both P <0 01).Conclusions:Imbalance of ET1/CGRP might be involved in the pathogenesis of MODS,and measurement of plasma ET1 and CGRP is of clinical significance in assessment of MODS prognosis and treatment of AHCVD with CGRP.