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| 经皮自体红骨髓移植治疗股骨骨不连的临床研究 | |
| 引用本文： | 李亚非,常红星,张建政,郭永智,潘德锦,方崇瑞,曹洪国,李东超,胡振中,邹宇伟,陈研,姚建华,马文辉,时述山,郭颖,齐立海,汪琦,王瑞敏. 经皮自体红骨髓移植治疗股骨骨不连的临床研究[J]. 中国医药, 2009, 4(12): 933-935. DOI: 10.3760/cma.j.issn.1673-4777.2009.12.002 |
| 作者姓名： | 李亚非 常红星 张建政 郭永智 潘德锦 方崇瑞 曹洪国 李东超 胡振中 邹宇伟 陈研 姚建华 马文辉 时述山 郭颖 齐立海 汪琦 王瑞敏 |
| 作者单位： | 1. 北京市健宫医院骨科,100054 2. 北京军区总医院骨科 3. 解放军总医院骨科 4. 河北省玉田县医院骨科 5. 河南省新乡辉县市医院骨科 6. 河北省唐山市第二医院骨科 7. 浙江省瑞安市中医院骨科 8. 北京燕化凤凰医院骨科 |
| 基金项目： | 国家自然基金资助项目 |
| 摘 要： | 目的探讨采用经皮自体红骨髓移植治疗股骨骨不连的效果。方法观察股骨骨不连患者82例，其中股骨粗隆下骨不连17例，股骨干骨不连52例，股骨髁上骨不连13例。用带锁髓内钉固定骨折端。取自体髂骨植骨。术后7d、15d骨折端注射复合骨形态发生蛋白的自体红骨髓。结果X线片显示2个月60例骨折端周围有大量新生骨痂，5个月75例有连续骨痂形成。平均愈合时间（7．2±1．8）个月。结论经皮自体骨髓干细胞复合骨形态发生蛋白移植，改善骨折区成骨能力，是治疗股骨骨不连的较好选择。 |
| 关 键 词： | 骨不连 骨髓干细胞 骨形态发生蛋白 |
Effect of percutaneous autogenous bone marrow transplant on femur nonunion |
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| LI Ya-fei,CHANG Hong-xing,ZHANG Jian-zheng,GUO Yong-zhi,PAN De-jin,FANG Chong-rui,CAO Hong-guo,LI Dong-chao,HU Zhen-zhong,ZOU Yu-wei,CHEN Yan,YAO Jian-hua,MA Wen-hui,Sill Shu-shan,GUO Ying,QI Li-hai,WANG Qi,WANG Rui-min. Effect of percutaneous autogenous bone marrow transplant on femur nonunion[J]. China Medicine, 2009, 4(12): 933-935. DOI: 10.3760/cma.j.issn.1673-4777.2009.12.002 | |
| Authors: | LI Ya-fei CHANG Hong-xing ZHANG Jian-zheng GUO Yong-zhi PAN De-jin FANG Chong-rui CAO Hong-guo LI Dong-chao HU Zhen-zhong ZOU Yu-wei CHEN Yan YAO Jian-hua MA Wen-hui Sill Shu-shan GUO Ying QI Li-hai WANG Qi WANG Rui-min |
| Affiliation: | . ( Department Orthopedics, Beijing Health Palace Hospital, Beijing 100054, China) |
| Abstract: | Objective To investigate the effect of percutaneous autogenous bone marrow transplant on fe-mur nonunion after operation. Methods Eighty-two patients of femur nonunion were treated with autologous bone grafting after the fracture fixation by interlocking nails. Autogenous bone marrow, combined with bone morphogenetic protein(BMP), was percutaneously injected into the fracture sites 7 and 14 days after the operation. Results Mas-sive callus formation could be observed in 60 cases 2 months after operation and continus callus were formed in in 75 cases in 5 months (mean time 7.2±1.8 months). Conclusion Percutaneous autogenous bone marrow transplant is an optimistic therapy for all indicated cases by improving activity of osteoblasts in fracture sites to accelerate fracture healing. |
| Keywords: | Bone marrow stem cell Nonunion Bone morphogenetic protein |
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