| 三种国产尼莫地平片剂的相对生物利用度研究 |
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| 引用本文： | 余自成 徐艳. 三种国产尼莫地平片剂的相对生物利用度研究[J]. 中国医药工业杂志, 1999, 30(8): 352-354 |
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| 作者姓名： | 余自成 徐艳 |
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| 作者单位： | [1]上海第二医科大学瑞金医院临床药理研究室 [2]河南石油勘探局职工医院 |
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| 摘 要： | ９例男性健康志愿者交叉口服Ａ、Ｂ、Ｃ３种国产尼莫地平片剂１２０ｍｇ,以ＨＰＬＣ法测定其血药浓度,研究了相对生物利用度。结果表明,尼莫地平在人体内的药动学符合开放两室模型,片剂Ｂ与Ａ相比,Ｃｍａｘ有显著差异,Ｂ的相对生物利用度为９４．７６％,片剂Ｃ与Ａ相比,Ｃｍａｘ差异极显著,ＡＵＣ有显著差异,Ｃ的相对生物利用度为６１．６７％。
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| 关 键 词： | 尼莫地平 生物利用度 高效液相色谱 片剂 |
RELATIVE BIOAVAILABILITY OF THREE DOMESTIC NIMODIPINE TABLETS IN HEALTHY VOLUNTEERS |
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| YU Zi Cheng ,XU Yan a,LU Shu,SHAO Yun Di,SHI Hao Qiang. RELATIVE BIOAVAILABILITY OF THREE DOMESTIC NIMODIPINE TABLETS IN HEALTHY VOLUNTEERS[J]. Chinese Journal of Pharmaceuticals, 1999, 30(8): 352-354 |
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| Authors: | YU Zi Cheng XU Yan a LU Shu SHAO Yun Di SHI Hao Qiang |
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| Affiliation: | YU Zi Cheng *,XU Yan a,LU Shu,SHAO Yun Di,SHI Hao Qiang |
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| Abstract: | The relative bioavailabilities of 3 domestic nimodipine(1) tablets(A,B and C) were investigated in 9 healthy male volunteers. A single oral dose of 120 mg of 1 tablets A,B or C was administered according to a randomized crossover design and blood concentrations of 1 were determined by HPLC. The pharmacokinetics of 1 conforms to open two compartment model. Compared with tablets A, C max was significantly lower for tablets B; for tablets C, C max was very significantly lower, AUC was significantly lower. The relative bioavailabilities of 1 tablets B and C were 94.76% and 61.67% respectively in comparison with tablets A. |
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| Keywords: | nimodipine bioavailability HPLC tablet |
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