透明质酸及其衍生物在骨组织应用中的研究进展

随着生物材料工程学不断发展,生物材料对骨科的发展起到非常重要的作用。由于透明质酸具有高度黏弹性、可塑性、超强的持水性、渗透性和良好的生物易吸收性等优势,同时改性的透明质酸不仅保持了原来的性能,还要完善它易降解、力学性能差等功能,使之更能适应人体,因此成为最近生物材料研究的新热点。本文就透明质酸及其衍生物在软骨缺损、骨修复等方面的研究现状,包括细胞在透明质酸的生长、动物试验、临床进展等进行概括,并分析了存在的问题及今后的发展方向。

Progress in hyaluronic acid and its derivatives in the bone tissue

Along with the continuous development of biomaterials engineering, biomaterials in orthopaedics updates constantly,which offers a new way for the development of orthopaedics. Hyaluronic acid is a new hotspot in the research of biological materials recently. Hyaluronic acid has high viscoelasticity, plasticity, super water-holding capacity, permeability and good biological absorptivity. Modification of hyaluronic acid not only keeps the original performance,but also improves the functions,and be more adaptive to the human body. This paper summarizes the research status of hyaluronic acid and its derivatives,analyzes the problems and prospects the development trends.