| 气道上皮屏障在支气管哮喘防御机制中的研究进展 |
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| 引用本文： | 游曼清,王宋平.气道上皮屏障在支气管哮喘防御机制中的研究进展[J].中华哮喘杂志（电子版）,2013(5):29-33. |
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| 作者姓名： | 游曼清 王宋平 |
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| 作者单位： | 泸州医学院附属医院呼吸内科,646000 |
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| 基金项目： | 四川省卫生厅科研项目（110341） |
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| 摘 要： | 支气管哮喘（简称哮喘）是一种气道慢性炎症性疾病，但是它的发病机制还不完全清楚。哮喘是由多种因素引起的复杂的疾病，气道上皮屏障的损伤是其主要特征。本文将对气道上皮屏障在哮喘中的防御机制作一综述。
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| 关 键 词： | 支气管哮喘 气道表面液体 上皮细胞 表皮生长因子受体 血管活性肠肽 锌 Toll样受体 紧密连接 |
Research progress the protective mechanism of airway epithelial barrier to bronchial asthma |
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| YOU Man- qing,WANG Song-ping.Research progress the protective mechanism of airway epithelial barrier to bronchial asthma[J].Chinese Journal of Asthma(Electronic Version),2013(5):29-33. |
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| Authors: | YOU Man- qing WANG Song-ping |
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| Institution: | . Department of Respiratory Disease, Luzhou Medical College Affiliated Hospital, Luzhou 646000, China |
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| Abstract: | Bronchial asthma （asthma） is a chronic inflammatory disorder of the airways, but its pathogenesis is incompletely understood. While asthma is a complex disease caused by multiple factors, airway epithelial barrier damage is a cardinal feature. We review the protective mechanism of airway epithelial barrier to asthma. |
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| Keywords: | Bronchial asthma Airway surface liquid Epithelial cell Epidermal growth factorreceptor VIP Zinc Toll-like receptors Tight j unctions |
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