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| 肿瘤坏死因子α抗体对大鼠胰性脑病保护作用的实验研究 | |
| 引用本文： | 杨雁灵,徐小平,窦科峰,李开宗. 肿瘤坏死因子α抗体对大鼠胰性脑病保护作用的实验研究[J]. 中国现代医学杂志, 2004, 14(12): 45-48 |
| 作者姓名： | 杨雁灵 徐小平 窦科峰 李开宗 |
| 作者单位： | 1. 第四军医大学西京医院肝胆外科,陕西,西安,710032 2. 第一军医大学珠江医院普通外科,广东,广州,510282 |
| 摘 要： | 目的探讨肿瘤坏死因子α(TNFα)抗体在大鼠急性出血坏死性胰腺炎时对脑组织损害的保护作用,从而为胰性脑病的治疗提供实验依据.方法将60只SD大鼠随机分为正常对照组,急性出血坏死性胰腺炎诱导组和TNFα抗体处理组,经胰胆管逆行注射5%牛磺胆酸建立大鼠ANP模型,测定血的TNFα水平,12 h后处死动物,检查胰腺组织形态学变化,并检测脑组织含水量、脑微血管内白细胞聚集及附壁现象.结果经TNFα抗体处理后,血清中TNFα水平、脑组织含水量、脑微血管内白细胞聚集及附壁现象显著降低(P＜0.05),胰腺组织病理损害程度减轻.结论TNFα抗体可以减轻急性出血坏死性胰腺炎时脑损害的发生和发展. |
| 关 键 词： | 胰腺炎 肿瘤坏死因子α 胰性脑病 大鼠 疾病模型 tumor necrosis factor α |
Protective effects of tumor necrosis factor antibody on pancreatic encephalopathy in rats |
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| Abstract. Protective effects of tumor necrosis factor antibody on pancreatic encephalopathy in rats[J]. China Journal of Modern Medicine, 2004, 14(12): 45-48 | |
| Authors: | Abstract |
| Abstract: | Objective:To study the protective effects of tumor necrosis factor α (TNF α) antibody on pancreatic encephalopathy in rats. Methods: 120 SD rats were randomly divided into the normal control group, acute necrotizing pancreatitis induction group and TNF α antibody treated group. Acute hemorrhagic necrotizing pancreatitis model in rats was induced by retrograde injection of 5% sodium taurocholate into the pancreatobiliary duct. Serum TNF αwas detected and animals were killed 12 h after drug administration. The changes of brain water contents, MDA content, leucocytes accumulation and adhesion of microvessels were measured. Results: In group of TNF α antibody treated, serum TNF α level decreased, brain water content, MDA content and leucocytes accumulation and adhesion decreased significantly compared to those of acute necrotizing pancreatitis induction group ( P ＜ 0.05 ). Conclusions:TNF α antibody can alleviate the brain damage in acute hemorrhagic necrotizing pancreatitis. |
| Keywords: | pancreatitis pancreatic encephalopathy rat disease model |
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