乙基叔丁醚对动物局部和全身的毒性研究

为了主人乙基叔丁醚（ＥＴＢＥ）的毒性作用，探讨它的灌注溶解治疗胆固醇结石的可能性。我们做了该药物的动物毒性实验，对比ＥＴＢＥ和ＭＴＢＥ（甲基叔丁醚）对动物的局部组织和全身毒性作用。局部毒性实验是对大白兔胆囊进行灌注后，病理观察组织变化。全身毒性实验是通过对小鼠腹腔注射药物的半致死量作对比。结果发现，ＥＴＢＥ对兔的胆囊、胆部属这和十二指肠的损害较ＭＴＢＥ组动物轻。ＥＴＢＥ摇篮腔注射半致死量ＬＤ５０）

Animal experiments of the systemic and local toxicity with ethyl tert-butyl ether(ETBE)

Inorder to evalute the toxicity of ETBE and probe into its clinical application, the authors had performed the following animal experiments. The local and systemic toxicity was observed experimentally to compare ETBE with MTBE (Methyl tert -- Butyl Ether). The local toxicity was found out from pathological changes of experimentally infused rabbit gallbladder. The systemic toxicity was proved by LD50 after peritoneal cavity injection. The autopsy of rabbits showed that ETBE produced less impairment to gallbladder, common bile duct and duodenum, LD50 of ETBE in peritoneal cavity increased 21 % than that of MTBE, (ETBE LD50 = 1. 80ml/kg, 95% CI= 1. 73- 2. 02ml/kg. MTBE LD50= 1. 58ml/kg, CI= 1. 42- 1. 67ml/kg). It was concluded that the systemic and local toxicity of ETBE was lower than that of MTBE, with no latent methanol. These studiexc would suggest that ETBE is a new and safe cholesterol gallstone contact solvent for treatment of cholecystolsithiasis.