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| 大肠癌组织中RB基因的点突变现象 | |
| 引用本文： | 李宇 司聚同. 大肠癌组织中RB基因的点突变现象[J]. 癌症, 1995, 14(1): 7-9 |
| 作者姓名： | 李宇 司聚同 |
| 作者单位： | 汕头大学医学院外科教研室，北京师范大学生物系细胞室，北京医科大学附属第一医院普外教研室 |
| 摘 要： | 为了进一步了解大肠癌中ＲＢ基因呈过度表达状态的机制，本文作者研究了ＲＢ基因存在点突变的可能性。利用ＲＮａｓｅ保护试验，在一例结肠癌中首次证实了其ＲＢ基因存在着点突变现象，同时也针对同大肠癌中ＲＢ基因过度表达相关的机制进行了讨论。 |
| 关 键 词： | 肿瘤 RB基因 基因表达 突变 |
THE POINT MUTATION OF Rb GENE IN COLORECTAL CARCINOMA |
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| Ll yu,SI Ju-tong,LI tong,WANG Yong-chao. THE POINT MUTATION OF Rb GENE IN COLORECTAL CARCINOMA[J]. Chinese journal of cancer, 1995, 14(1): 7-9 | |
| Authors: | Ll yu SI Ju-tong LI tong WANG Yong-chao |
| Abstract: | To obtain further insight into the mechanism of Rb gene overexp-ression in colorectal carcinomas,we had investigated the possibility of point mutation inthe Rb gene Using RN ase protection assay,we found for the first time the point muta-tion of Rb gene in one tumor,Possible mechanfsms pertaining to the overex pression ofthe Rb gene were discussed. |
| Keywords: | Colorectal carcinoma Rb gene Overexpressin of genepoint mutation of gene1.Department of Bidology Beijng Normal University2.Departinent of Surgery the First Teaching Hospital Beijing Medical University |
| 本文献已被 CNKI 维普 等数据库收录！ | |