丹参多酚酸盐联合盐酸纳美芬对急性重度酒精中毒患者的临床疗效

目的探讨丹参多酚酸盐联合盐酸纳美芬对急性重度酒精中毒患者的临床疗效。方法 83例患者随机分为对照组(41例)和观察组(42例),对照组给予盐酸纳美芬,观察组在对照组基础上加用丹参多酚酸盐,疗程3 d。然后,检测临床疗效、症状缓解时间、清醒时间、心肌酶(CK、cTnI、CK-MB)、神经递质(DA、NE、5-HT)变化。结果观察组总有效率显著高于对照组(P<0.05),症状缓解时间、清醒时间显著缩短(P<0.05)。治疗后,2组心肌酶活性、神经递质水平显著降低(P<0.05),以观察组更明显(P<0.05)。结论丹参多酚酸盐联合盐酸纳美芬可改善急性重度酒精中毒患者心肌酶活性和神经递质水平,临床疗效明显。

Clinical effects of salvianolate combined with namefen hydrochloride on patients with acute severe alcoholism

AIM To explore the clinical effects of salvianolate combined with namefen hydrochloride on patients with acute severe alcoholism. METHODS Eighty-three patients were randomly assigned into control group(41 cases) for 3-day administration of namefen hydrochloride, and observation group(42 cases) for 3-day administration of salvianolate and namefen hydrochloride. Subsequently, the changes in clinical efficacy, symptom relief time, awake time, myocardial enzymes(CK, cTnI, CK-MB) and neurotransmitters(DA, NE, 5-HT) were detected. RESULTS The observation group demonstrated significantly higher total effective rate than the control group(P<0.05), as well as markedly shortened symptom relief time and awake time(P<0.05). After the treatment, the two groups displayed significantly decreased myocardial enzyme activities and neurotransmitter levels(P<0.05), and the observation group took the lead(P<0.05). CONCLUSION For the patients with acute severe alcoholism, salvianolate combined with namefen hydrochloride can improve myocardial enzyme activities and neurotransmitter levels, exhibiting obvious clinical efficacy.