血管性认知障碍发病机制的研究进展

目前,血管性痴呆(vascular dementia,Va D)患者逐年增多,仅次于阿尔茨海默病(Alzheimer's disease,AD),居于痴呆发病原因第二位。而血管性痴呆是唯一可通过早诊断、早治疗达到控制病情进展,甚至达到临床痊愈的痴呆。VaD是由血管性认知障碍(vascular cognitive impairment,VCI)发展而来。由此可见,了解血管性认知障碍的发病机制,研究出早期防治的有效方法,具有重要的临床意义和社会价值。本文通过回顾近几年的相关文献,较为系统的阐述了VCI的发病机制,从影像学、病理生理学以及关键部位等几方面的研究进展进行重点介绍。

Progress in the pathogenesis of vascular cognitive impairment

At present,patients with vascular dementia(VaD)are increasing year by year,ranking second in the cause of dementia,second only to Alzheimer''s disease(AD).Vascular dementia is the only dementia that can be controlled by early diagnosis and early treatment and even cured.VaD is progressed from vascular cognitive impairment(VCI).It can be seen that understanding the pathogenesis of vascular cognitive impairment and studying effective methods for early prevention and treatment have important clinical and social value.By reviewing the relevant literatures in recent years,this paper systematically expounds the pathogenesis of VCI,focusing on the research progress in imaging,pathophysiology and key sites.