促甲状腺激素抑制治疗对分化型甲状腺癌患者甲状腺功能的影响

目的观察促甲状腺激素(TSH)抑制治疗对分化型甲状腺癌患者甲状腺功能的影响及抑制肿瘤复发的效果。方法选取2012年1月～2013年6月我院收治的58例分化型甲状腺癌患者为研究对象,按照其病理类型将其分为甲组(乳头状癌)34例与乙组(滤泡状癌)24例,均给予TSH抑制治疗,对比两组患者的治疗效果、甲状腺功能变化情况及预后。结果甲组总有效率为91.18%,乙组总有效率为91.67%,组间比较差异无统计学意义(P0.05);治疗前,两组甲状腺功能各指标比较,差异无统计学意义(P0.05);治疗后两组患者甲状腺功能与治疗前比较,均优于治疗前,差异有统计学意义(P0.05),但两组治疗后数据对比,差异无统计学意义(P0.05)。且两组患者肿瘤复发率、颈部淋巴结转移率、远处转移率比较,差异无统计学意义(P0.05)。结论 TSH抑制治疗对分化型甲状腺癌患者的价值显著,可有效改善患者甲状腺功能及抑制肿瘤复发,临床推广价值高。

Effect of thyroid stimulating hormone on thyroid function in patients with differentiated thyroid cancer

Objective To observe the effect of TSH(Thyroid Stimulating Hormone)on the thyroid function and the inhibition of tumor recurrence in patients with differentiated thyroid cancer.Methods 58 patients with differentiated thyroid cancer admitted in our hospital from January 2012 to June 2013 were enrolled in the study.According to their pathological types,they were divided into group A(papillary carcinoma,n=34)and group B(n=24).They were all treated with TSH inhibition.The treatment effects,thyroid function changes and prognosis were compared between the two groups.Results The total effective rate was 91.18%in group A and 91.67%in group B.The difference was not statistically significant(P>0.05).There was no significant difference in thyroid function between the two groups before treatment(P>0.05).The thyroid function of the two groups after treatment was better than that before treatment,which was statistically significant(P<0.05).But there was no significant difference between the two groups after treatment(P>0.05).There was no significant difference in tumor recurrence rate,cervical lymph node metastasis rate and distant metastasis rate between the two groups(P>0.05).Conclusion TSH inhibition therapy for differentiated thyroid cancer has significant value,which can effectively improve the thyroid function of the patient and inhibit the tumor recurrence,and has high clinical promotion value.