同型半胱氨酸、血清胱抑素C、超敏C反应蛋白联合检测在糖尿病肾病早期诊断中的应用

目的探讨同型半胱氨酸、血清胱抑素C、超敏C反应蛋白联合检测在糖尿病肾病早期诊断中的应用。方法选择2018年1月～2019年1月我院住院治疗的2型糖尿病患者97例作为研究对象,根据24 h尿清蛋白排泄量分为三组:单纯糖尿病组30例、早期糖尿病肾病组32例、临床糖尿病肾病组35例。另选择同期健康体检者40例作为对照组,比较各组同型半胱氨酸、血清胱抑素C、超敏C反应蛋白水平。结果早期糖尿病肾病组患者血清同型半胱氨酸、血清胱抑素C、超敏C反应蛋白与对照组比较差异有显著性,显著高于健康对照组和正常对照组,但明显低于临床糖尿病肾病组(P0.01)。32例早期糖尿病肾病患者中胱抑素C阳性16例,阳性率为50.0%,hs-CRP阳性17例,阳性率为53.1%,Hcy阳性15例,阳性率为46.9%,三项指标联合检测阳性率25例,阳性率为78.1%,三项指标联合检测的阳性率分别显著高于其他指标单独检测的阳性率,差异具有显著性(P0.05)。结论同型半胱氨酸、血清胱抑素C、超敏C反应蛋白联合检测在糖尿病肾病早期诊断中的应用效果确切,有利于病情严重程度的判断。

Application of combined detection of homocysteine,serum cystatin C and high-sensitivity C-reactive protein in early diagnosis of diabetic nephropathy

Objective To investigate the application of homocysteine,serum cystatin C and high-sensitivity C-reactive protein in the early diagnosis of diabetic nephropathy.Methods 97 patients with type 2 diabetes mellitus who were admitted to our hospital from January 2018 to January 2019 were selected as study subjects.According to the volume of 24 h urinary albumin excretion,the patients were divided into three groups:30 patients in the simple diabetes group,32 patients in the early diabetic nephropathy group,and 35 patients in the clinical diabetic nephropathy group.Another 40 healthy people during the same period were selected as the control group.The levels of homocysteine,serum cystatin C,and high-sensitivity C-reactive protein were compared between the groups.Results Serum homocysteine,serum cystatin C,and high-sensitivity C-reactive protein in the early diabetic nephropathy group were significantly different from those in the control group,which was significantly higher than that in the healthy control group and the normal control group.However,they were significantly lower than those in the clinical diabetic nephropathy group(P<0.01).Among the 32 patients with early diabetic nephropathy,16 cases were positive for cystatin C,and the positive rate was 50.0%.17 cases were positive for hs-CRP,and the positive rate was 53.1%.15 cases were positive for Hcy,and the positive rate was 46.9%.25 cases were positive for combined detection of the three indicators,and the positive rate was 78.1%.The positive rate of the combined detection of the three indicators was significantly higher than that of the other indicators,and the differences were significant(P<0.05).Conclusion The combined detection of homocysteine,serum cystatin C and high-sensitivity C-reactive protein in the early diagnosis of diabetic nephropathy is effective,which is conducive to the judgment of the severity of the disease.