| 细胞损伤修复法和钙蛋白酶抑制法测定脑蛋白水解物注射液活性的比较研究 |
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| 引用本文： | 蒋玉辉,梁蔚阳. 细胞损伤修复法和钙蛋白酶抑制法测定脑蛋白水解物注射液活性的比较研究[J]. 药物分析杂志, 2011, 0(1) |
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| 作者姓名： | 蒋玉辉 梁蔚阳 |
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| 作者单位： | 广东省药品检验所; |
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| 基金项目： | 科技部“十一五”国家科技支撑计划项目(2008BAI55B04-3-3); 广东省药品检验所所内课题项目(SN20071212) |
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| 摘 要： | 目的:为脑蛋白水解物注射液活性检测方法的建立提供依据。方法:采用PC12细胞过氧化氢损伤修复法和钙蛋白酶抑制法对脑蛋白水解物注射液的活性进行检测。结果:2种方法均可检测出样品的活性。结论:2种方法各有优缺点,尚需进一步验证。
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| 关 键 词： | 脑蛋白水解物注射液 生物活性 |
Comparison of repairing injured PC12 cells and inhibiting calpain for determining the bioactivity of cerebroprotein hydrolysate injection |
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| JIANG Yu-hui,LIANG Wei-yang. Comparison of repairing injured PC12 cells and inhibiting calpain for determining the bioactivity of cerebroprotein hydrolysate injection[J]. Chinese Journal of Pharmaceutical Analysis, 2011, 0(1) |
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| Authors: | JIANG Yu-hui LIANG Wei-yang |
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| Affiliation: | JIANG Yu-hui,LIANG Wei-yang(Guangdong Institute for Drug Control,Guangzhou 510180,China) |
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| Abstract: | Objective:To provide the foundation of developing the methods for determining bioactivity of cerebroprotein hydrolysate injection.Methods:The bioactivity of cerebroprotein hydrolysate injection was determined by repairing injured PC12 cells and inhibiting calpain.Results:The bioactivity of all the six samples could be determined by the both methods.Conclusion:The tow methods both have superiorities and deficiencies,and both need more validation. |
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| Keywords: | cerebroprotein hydrolysate injection bioactivity |
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