难治性癫痫脑干听觉诱发电位与认知功能的临床研究

目的:探讨难治性癫痫脑干听觉诱发电位(ABR)与认知功能状况。方法:对25例难治性癫痫患者进行ABR、认知功能(CCSE)、简易智力状态试验(MMSE)的测定。结果:难治性癫痫的部分性发作与全身性发作ABR提示:Ⅲ、Ⅴ波潜伏期均延长,两者比较无显著差异,认知功能得分均明显降低,且全身性发作较部分性发作认知功能损伤更为严重,两者有显著性差异。病程>5年组及1～5年组ABR均提示脑干功能障碍。半年～1年组ABR大致正常,认知功能测定:>5年组和1～5年组CCSE、MMSE得分均降低,>5年组认知损害更重,有显著差异,半年～1年组得分大致正常。结论:全身性发作较部分性发作对认知功能损伤更重,病程越长,ABR的Ⅲ、Ⅴ波潜伏期延长越显著、对认知功能损伤越重。

CLINICAL STUDY ON BRAINSTEM AUDITORY EVOKED POTENTIALS AND COGNITIVE FUNCTION IN PATIENTS WITH REFRACTORY EPILEPSY

Objective: To study the brainstem auditory evoked potentials - ( ABR) and the cognitivefunction in patients with refractory epilepsy. Methods: ABR, cognitive capacity screening examination (CCSE) and mini - mental state examination (MMSE) were done separately in 25 patients with refractory epilepsy. Results : The Latency of III , V wave of ABR prolonged. No significant difference was observed in the latency of ABR between patients with partial serzure and patients with generalized seizure. Both CCSE and MMSE marks were lower. the generalized seizure was more serious than partial seizure. Significant difference was observed in CCSE and MMSE marks. ABR showed that function of brainstens was disturbed in patients with disease course of over five years and between one year and not more than five years, ABR showed normal with disease conrse of less than one year. Cognitive function: Both CCSE and MMSE marks were lower in patients with disease Course of over five years and between one year and not more tham five years, It was more serious in disease course over five years. Significant difference was observed. Both CCSE and MMSE marks were normal in patients with disease course less than one year. Conclusion: CCSE and MMSE were more serious in patients with generalized seizure than those in partial seizure. The longer the course of the disease, the more signiffcant prolonged latency of III , V wave of ABR, the more serious of CCSE and MMSE.